- Side Effects
- Patient Information Leaflet
What is Evorel Patches
Evorel Patch is an oestrogen-only Hormone Replacement Therapy (HRT) for oestrogen deficiency symptoms in pre and post-menopausal women. Evorel is a patch that gradually releases hormones into the body. The treatment is suitable for you if you have difficulty swallowing tablets or if you have trouble remembering to take a medicine every day. Evorel is a patch placed on the skin and changed twice weekly.
Evorel Patches are an easy way to ease the annoying and life-altering symptoms of menopause, like hot flushes, strong heartbeat, osteoporosis, dryness of the eyes, mood swings, reduced sex drive, night sweats, vaginal dryness, irritability, insomnia, and pain during sex.
The ingredient released is estradiol, which emulates the female sex hormone oestrogen. It is absorbed slowly through the skin without the need to apply cream or swallow tablets. These patches reduce the risk of developing some cancers for women with an intact uterus compared to some other HRT options.
Can I buy Evorel Patches online?
You can purchase Evorel Patches online via Click Pharmacy. First, you have to complete a health questionnaire. Then, our in-house doctors will assess it for the eligibility criteria. Finally, specific contraindications for HRT arise questions, like information on whether you have had a hysterectomy or the severity of your symptoms. Once approved for the treatment, you may purchase it immediately. We will send your Patches out to you quickly and discreetly.
How effective is the Evorel Patch?
Evorel Patches are ideal for women who do not have a uterus. It also effectively relieves menopausal symptoms in women who have not had a hysterectomy and therefore require the hormone oestrogen. Evorel Patches are suited for women who have already reached menopause but still suffer distressing symptoms. They are also beneficial for post-menopausal women who are more likely to suffer osteoporosis-related bone issues.
Why choose the Evorel Patch?
Evorel patch is a quick and straightforward way to receive the exact dose of oestrogen you require daily. In addition, it frees you from forgetting to take a tablet or worrying about applying the cream.
Evorel Patch is a convenient alternative for patients who cannot or prefer not to swallow tablets every day. The quick and easy application means you receive the hormone you need without worrying about forgetting to take it or anyone else being affected.
What is contained in the Evorel Patch?
The active ingredient in the Evorel patch is estradiol hemihydrate.
The inactive ingredients are:
- Duro-Tak 387-2287, which makes the patches stick
- Guar gum
- Hostaphan MN19 on the backing film.
In case of any allergic responses, consult your GP or Click pharmacy doctor before going ahead and purchasing your prescription.
What dose should I choose?
Take the lowest effective dosage for the minimum duration for the initiation and continuation of treatment. Your GP will monitor your reaction to the medication before confirming which dosage is best. The treatment regimen with the Evorel Patch may be either cyclic or continuous sequential.
Evorel is a patch placed on the skin and is changed twice weekly. Evorel is a square-shaped, transparent, self-adhesive transdermal delivery system (Patch) of 0.2 mm thickness for application to the skin surface. Evorel is available in four sizes with four different concentrations:
- Evorel 25 is marked CE25 and contains 1.6 mg estradiol with a release rate of 25 micrograms of estradiol in 24 hours.
- Evorel 50 is marked CE50 and contains 3.2 mg estradiol with a release rate of 50 micrograms of estradiol in 24 hours.
- Evorel 75 is marked CE75 and contains 4.8 mg estradiol with a release rate of 75 micrograms of estradiol in 24 hours.
- Evorel 100 is marked CE100 and contains 6.4 mg estradiol with a release rate of 100 micrograms of estradiol in 24 hours.
How should I use the Evorel Patch?
Post-menopausal women currently not on HRT may start Evorel at any time. Peri-menopausal women still having regular menstrual cycles and are not presently on HRT should start Evorel within 5 days of bleeding.
Evorel Patches are for transdermal use; apply a patch to the skin on the buttocks or hips, changing and rotating sites twice a week. You can wear the patches continuously without a break. Do not apply to the skin on or around the breasts.
Patches may be worn under loose-fitting clothing. However, be careful not to place your patch under tight or elasticated waistbands.
How to apply the Evorel Patch?
- Before application, wash the skin and dry it thoroughly
- Remove the Evorel Patch from its pouch and peel off half the protective liner from the back of the patch.
- Place the Evorel Patch onto the desired area of hairless, intact skin, sticky side down. Next, peel off the other half of the liner, pressing the patch down onto the skin for 30 seconds.
How do Evorel Patches work?
Evorel patch works by supplying the body with oestrogen via the skin to compensate for a loss of this hormone. The active ingredient is estradiol, also referred to as oestradiol, which is oestrogen in a synthetic form. Evorel patch slowly releases estradiol which imitates the action of the female sex hormone oestrogen.
Evorel Patch is an HRT containing the sex hormone affected during menopause. Oestrogen is depleted during this time, which results in the unpleasant and unwanted side effects that many women experience. By topping up the decreasing oestrogen levels with estradiol, many women experience ease in issues such as night sweats and mood swings.
For women with an intact uterus, progestogen must typically be added to Evorel to prevent adverse endometrial effects, like hyperplasia and cancer.
For how long can I use Evorel Patches?
You can use Evorel Patches for several years to ease the side effects of menopause. In the UK, the average menopause age in women is 51, though some women start normal menopause as early as 45. So, premature menopause would start earlier than this. In most situations, menopausal symptoms usually last between 4 and 5 years; HRT may be used during this time.
It is better to have annual gynaecological checkups and a medication review to ensure you are still on the safest and most beneficial form of HRT for your health.
What are the side effects of the Evorel Patches?
Aside from the benefits of Evorel Patches, there are potential side effects which may be experienced by some women and not by others. Doctors usually recommend waiting at least 12 weeks before changing HRT so your body may get used to the effects of the hormones and balance out. After this time, most women find their side effects disappear. However, if you are concerned, you may speak to your doctor anytime about the side effects you experience.
The common side effects of the patch are headache, breast tenderness/pain, nausea, diarrhoea, stomach pain, painful joints, tingling in the hands or feet, vaginal bleeding or discharge, breakthrough bleeding, uterine disorders, anxiety, mood swings, water retention, fatigue, dizziness, weight gain, itchiness or inflamed skin where the patch is applied.
Stop using Evorel Patch and seek medical attention immediately if you notice early signs of any of the following:
• Blood clots – pain and swelling of the legs, difficulty breathing.
• Stroke – sudden migraines, blurred vision.
• Heart disease – chest pain which extends to the neck or arm.
• Liver disease – yellow colouration of the skin or eyes.
If you are concerned about the adverse effects, or if the product affects you in any other way, stop using it immediately and talk to your doctor or a health care expert at Click Pharmacy.
Other Warnings to consider
HRT pose an increased risk of developing breast cancer, endometrium or ovaries. However, combined HRTs such as Evorel Patches help to lower this risk in women who have not had their wombs removed.
Evorel Patches are not recommended for women with heart disease or a heart attack, as HRT may affect the heart and circulation.
Blood clots are likely to occur in HRT users. The risk of developing them, especially in the first year of using a treatment, may be increased in certain situations if you:
● May have cancer which is sensitive to oestrogen (including uterine cancer)
● Suffer from a blood clotting disease, or have ever had a blood clot
● Ever had breast cancer
● Have untreated endometrial hyperplasia (an excessively thick womb lining)
● Are pregnant or breastfeeding
● Have recently had a heart attack or stroke
● Have unexplained vaginal bleeding
● Suffer from porphyria (a rare hereditary blood disease)
● Have a history of liver disease
● Are allergic to the ingredients of the patch
Inform your GP if you plan to use Evorel Patch and have ever had any of the following health complications:
● Impaired liver function
● Uterine problems, including endometriosis or endometrial hyperplasia
● Circulation problems (e.g. angina, heart attack)
● High risk of blood clots
● Systemic lupus erythematosus
● High-fat levels in the blood
● Fluid retention
● History of severe allergic reactions
● High blood pressure
● Otosclerosis (a hereditary ear disorder)
● A family history of breast cancer or another oestrogen-sensitive cancer
Evorel vs. Evorel Sequi vs. Evorel Conti
Evorel only contains estradiol (oestrogen). It is prescribed for women who have had their uteruses removed or those with a Mirena coil fitted.
Evorel Sequi is a sequential combined HRT containing estradiol (an oestrogen) and norethisterone (a progestogen). Generally, it is used in women who have an intact womb. The norethisterone in Evorel Sequi contradicts the thickening effect of estradiol on the womb's lining. This reduces the risk of developing endometrial cancer.
Similarly, Evorel Conti is a continuous combined form of HRT. It contains estradiol (oestrogen) and norethisterone (a progestogen). However, the critical difference is that Evorel Conti is continuous. This means that each patch consists of both hormones. Due to this, women will also experience their menstrual cycle.
Alternatives to HRT
Although HRT is one of the most effective treatments for the symptoms of menopause, some people prefer to treat their symptoms with alternatives, such as herbal supplements. However, the efficacy of HRT holds some weight, while there is not enough evidence to support the effectiveness of herbal treatments. Therefore, seeking a doctor's or pharmacist's advice about the effectiveness level of herbal supplements before trying them is essential.
Lifestyle changes to improve menopause symptoms
You can make some lifestyle changes to help manage the symptoms of menopause and increase the efficacy of HRT.
For instance, you can increase your vitamin D intake, as it helps keep your bones strong and healthy. You can also try to exercise on a regular basis to boost your heart health while cutting down on stress. In addition to this, you should eliminate caffeine, alcohol, and spicy foods from your diet. Finally, avoiding smoking is vital as it can reduce symptoms such as hot flashes and night sweats.
Also, you can use OTC moisturisers and lubricants if you suffer from vaginal dryness.
Are Evorel patches safe?
Yes, Evorel patches are safe. In general, Evorel patches are used by most menopausal and postmenopausal women – particularly those who have had a hysterectomy or have endometrial protection. While the type of HRT you choose depends entirely on personal preference, a few benefits are associated with patches instead of oral types of HRT.
Since patches are applied directly to the skin, they result in fewer side effects than oral HRTs. Additionally, patches have fewer interactions with other medications and do not interfere with your sex drive.
Will I need to take Evorel for the rest of my life?
No. During the initial stages, you will be prescribed the lowest dose of Evorel. Also, it will be prescribed for a short amount of time. This is because HRT's risks and potential side effects continue to increase with time and age. However, your GP will inform you whether it is okay for you to stop using Evorel or not. Note that women over 65 should not take HRT.
Can Evorel patches be cut in half?
Absolutely not. Do not ever cut Evorel patches in half. Cutting the medicine in half will alter the mechanism of the dose. As a result, you will not receive the proper amount of the dose that your system requires, which will render the medication useless.
Pregnancy and Lactation
You should not use Evorel if you are pregnant or are planning to get pregnant. Evorel is not indicated during pregnancy under any circumstances. However, you should halt the use of the treatment if you become pregnant. It is a treatment containing estrogen, and an excess of the hormone in the body can harm the fetus.
Similarly, Evorel should not be used if you are lactating or breastfeeding.
Non-medicinal alternatives for the symptoms of menopause
There are various non-medicinal alternatives for the symptoms of menopause that you can use combined with Evorel. These can further help reduce and manage the occurrence of symptoms.
For symptoms like night sweats and hot flashes, try using a fan, taking cold showers, and wearing light items of clothing made out of cotton. For vaginal dryness, try OTC moisturisers and lubricants. In addition, make sure you have a healthy diet, exercise regularly, and avoid bad lifestyle habits like smoking.
What is menopause?
Menopause is a condition in a woman’s life when she no longer has a menstrual cycle and cannot have a pregnancy naturally.
At what age the menopause start?
Women usually have menopause at the age of 51. The average range is between the ages of 45 and 55.
What are the risks of HRT?
Women receiving HRT can experience vaginal bleeding, headaches, and breast tenderness.
What is Osteoporosis?
The weakening of the bones due to reduced oestrogen levels is osteoporosis. It is more common in women who have reached menopause. Oestrogen from HRT may prevent osteoporosis in the short term. However, once you stop HRT, you may experience osteoporosis again.
What is the active ingredient of the Evorel Patch?
The active ingredient in the Evorel patch is estradiol hemihydrate.
How can I use Evorel Patch?
Evorel is a patch placed on the skin and is changed twice weekly.
For how long can I use Evorel Patch?
You can use Evorel Conti Patch for several years to ease the side effects of menopause.
● Breast tenderness/pain
● Stomach pain
● Painful joints
● Water retention
● Tingling in the hands or feet
● Vaginal bleeding or discharge
● Itchiness or inflamed skin where the patch is applied
● Breakthrough bleeding
● Mood swings
● Weight gain