Medication features:

  • Hormone replacement therapy for estrogen deficiency
  • Contains conjugated oestrogens
  • For postmenopausal women


Available strengths:

0.3mg 0.625mg 1.25mg


Price £22.99

Includes free private prescriptions

In stock

Delivery Time


Expected delivery date:

Wednesday, 13 December 2023

If you order within:


Next Day Delivery

Next Day

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UK Registered Pharmacy

UK Registered

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  • Overview
  • FAQ
  • Side Effects
  • Patient Information Leaflet
  • Reviews

What is Premarin

Premarin Tablets are a hormone replacement therapy (HRT) for estrogen deficiency in postmenopausal women. It effectively eases the symptoms of menopause and prevents osteoporosis in postmenopausal women at high risk of future fractures who are contraindicated to or intolerant of other medicinal products approved for the prevention of osteoporosis. Premarin contains conjugated oestrogens, which emulate the female sex hormone oestrogen.

Premarin Tablets are an easy way to ease the life-altering and annoying symptoms of menopause, like hot flushes, strong heartbeat, osteoporosis, dryness of the eyes, mood swings, reduced sex drive, night sweats, vaginal dryness, irritability, insomnia, and pain during sex.

Can I buy Premarin Tablets online?

You can purchase Premarin Tablets online via Click Pharmacy. First, you have to complete a health questionnaire. Then, our in-house doctors will assess it for the eligibility criteria. Finally, specific contraindications for HRT arise questions, like information on whether you have had a hysterectomy or the severity of your symptoms. Once approved for the treatment, you may purchase it immediately. We will send your Premarin Tablets out to you quickly and discreetly. You may then order again in the future without re-doing the assessment.

If you find this is not the correct or most appropriate treatment. In that case, you can discuss this in a free online appointment with our doctor and find another HRT treatment that will be more beneficial.

How effective are the Premarin Tablets?

Premarin Tablets are effective even at low doses to relieve postmenopausal symptoms. Depending on your condition and where you are in your menopause journey, you may take it short or long-term. It prevents osteoporosis (fragile bones) in women who have had menopause and are most likely to have bone problems.

The drug may also effectively prevent osteoporosis for women with a heightened risk of fractures if they cannot take any other form of prevention medication. This can occur as the bone-strengthening and protecting hormone oestrogen decreases during menopause.  

The effects of the Premarin Tablets kick in relatively quickly, with many women experiencing the benefits within just a few weeks.  

Why choose the Premarin Tablets?

Premarin Tablets may play a massive role in helping women feel better despite being seriously affected by menopausal symptoms. By replacing the depleted hormones, the medication helps to stop crippling symptoms such as insomnia, headaches, memory loss and more. In addition, HRT treatments such as Premarin Tablet also support menopausal low moods and anxiety.

For how long can I use the Premarin Tablets?

You may use Premarin Tablets for several years to ease the side effects of menopause. In the UK, the average menopause age in women is 51, though some women start normal menopause as early as 45. Premature menopause would be earlier than this. Menopausal symptoms usually last between 4 and 5 years, so in most situations, HRT may be used during this time.

HRT must only be necessary as a relatively short-term treatment as your body adjusts to menopause. You should review your HRT with your GP at least once each year and have regular gynaecological checkups.

What is contained in the Premarin Tablets?

The active ingredient in the Premarin Tablet is conjugated estrogen.

The inactive ingredients are:  

● Lactose Monohydrate (spray dried)
● Microcrystalline Cellulose
● Hypromellose 2208, K100M (100,000 cps)
● Magnesium Stearate

The ingredients in the film-coating material are:

● Sucrose
● Microcrystalline Cellulose
● Hydroxypropyl Cellulose
● Hypromellose, 2910, E6 (6 cps)
● Hypromellose, 2910, E15 (15 cps)
● Polyethylene Glycol 400

The edible ink contains propylene glycol and either titanium dioxide (E171) or iron oxide black (E172).

● The green tablets contain quinolone yellow (E104), indigo carmine (E132) and polysorbate 80.
● The maroon tablets contain red aluminium lake (E129) and indigo carmine (E132).
● The yellow tablets contain quinolone yellow (E104), sunset yellow (E110) and polysorbate 80

In case of any allergic responses, consult your GP or Click pharmacy doctor before going ahead and purchasing your prescription.

What dose should I choose?

Start with the minimum effective dose for the shortest duration for the initiation and continuation of treatment. Premarin 0.3-1.25 mg daily is the usual starting dose for women without a uterus. Doctors recommend continuous administration.

Premarin Tablets are available in the following strengths:

  • 3 mg pack-contains green oval, biconvex sugar-coated tablets, marked with 0.3, containing 0.3 mg conjugated estrogens
  • 625 mg pack-contains maroon oval, biconvex sugar-coated tablets, marked with 0.625, containing 0.625 mg conjugated estrogens
  • 25 mg pack- contains the yellow oval, biconvex sugar-coated tablets, marked with 1.25, containing 1.25 mg conjugated estrogens

Your doctor will tell you which strength you need to take, depending on your symptoms and risks.

How should I use the Premarin Tablets?

Take one tablet daily with a drink, either with or without a meal. Take the tablet at a fixed time daily for the best results. Only take medicine if you remember to take a missed dose within 12 hours; if you remember after it, skip the dose. Do not double up or take two within 12 hours of each other.

Do not take breaks between your packs of Premarin Tablets. However, have your treatment reviewed at least once a year to ensure you are still using the best form of medication and receiving the most significant benefits from it.

How do Premarin Tablets work?

Premarin Tablets work by restoring the hormonal balance in the body, reducing or preventing menopausal symptoms from occurring. Hormone Replacement Therapy (HRT) eases the symptoms of menopause by supplementing the levels of hormones that the body can produce naturally.

Premarin Tablets contain conjugated oestrogens, which are natural forms of oestrogen. Suppose you have had a hysterectomy (an operation to remove the uterus) in that case, oestrogen is the only hormone you require to replace.

If you haven’t had your uterus removed, you may be prescribed a progestogen medicine alongside Premarin. When oestrogen levels increases, the lining of the uterus (the endometrium) grows excessively. This will substantially increase the risk of complications like endometrial cancer. If you have not had a hysterectomy, you may be prescribed another medicine that provides combined HRT.

What are the side effects of the Premarin Tablets?

Apart from the benefits of Premarin Tablets, there are potential side effects. These may be experienced by some women and not by others. Doctors usually recommend waiting at least 12 weeks before changing HRT as your body may get used to the effects of the hormones and balance out. After this time, most women find their side effects disappear. However, you may speak to your doctor anytime if you are concerned.

The potential side effects of the Premarin Tablet are headache, migraine, breast tenderness/pain, nausea, bloating, abdominal pain, painful joints, leg cramps, tingling in the hands or feet, vaginal bleeding or discharge, breakthrough bleeding, leucorrhoea, thrush, anxiety, depression, changes in libido, mood swings, and weight loss/gain.

Stop using Premarin Tablets and seek medical attention immediately if you notice early signs of any of the following:

  • Blood clots – pain and swelling of the legs, difficulty breathing
  • Stroke – sudden migraines, blurred vision
  • Heart disease – chest pain which extends to the neck or arm
  • Liver disease – yellow colouration of the skin or eyes.

If these adverse effects bother you or the product affects you in any other way, stop using Premarin immediately and talk to your doctor or pharmacist. You may book a free and confidential appointment with our online specialist at Click Pharmacy anytime.

Other Warnings to consider

HRT pose an increased risk of developing breast cancer, endometrium or ovaries. However, Premarin Tablets help to lower this risk in women who have not had their wombs removed.  

Premarin Tablets are not recommended for women with heart disease or a heart attack, as HRT may affect the heart and circulation.

Blood clots may occur in HRT users. The risk of blood clots doubles if you: 

● Ever had breast cancer
● May have cancer which is sensitive to oestrogen (including uterine cancer)
● Have untreated endometrial hyperplasia (an excessively thick womb lining)
● Suffer from a blood clotting disease or have ever had a blood clot
● Have recently had a heart attack or stroke
● Have unexplained vaginal bleeding
● Have a history of liver disease
● Suffer from porphyria (a rare hereditary blood disease)
● Are allergic to the ingredients of  the patch
● are pregnant or breastfeeding

Inform your GP if you plan to use Premarin Tablets and have ever had any of the following health complications:

● Fibroids
● Impaired liver function
● Uterine problems, including endometriosis or endometrial hyperplasia
● Circulation problems (e.g. angina, heart attack)
● High risk of blood clots
● Diabetes
● Migraine
● Gallstones
● Systemic lupus erythematosus
● Asthma
● Epilepsy
● Fluid retention
● High blood pressure
● High-fat levels in the blood
● Otosclerosis (a hereditary ear disorder)
● Low calcium levels in the blood
● A family history of breast cancer or another oestrogen-sensitive cancer
● History of severe allergic reactions 

Alternatives to Premarin

Other types of HRT that act as alternatives to Premarin include:

  • Skin patches
  • Skin gels
  • Vaginal rings
  • Vaginal creams
  • Vaginal pessaries

Alternative treatments to Premarin are:

  • Kliovance
  • Livial
  • Elleste Solo
  • Evorel Sequi patches
  • Premique
  • Elleste Duet Conti
  • Elleste Duet

Does Premarin cause weight gain?

Yes. A potential side effect of Premarin is weight gain. However, not every individual who takes weight gain will experience this. Also, note that women can gain weight during menopause naturally.

How long does Premarin take to work?

Premarin is an HRT, which means that the full effects of HRT can take around three to four months to work properly. But, sometimes, women may experience the benefits of Premarin within a few weeks of starting treatment.

What happens when you stop taking Premarin?

HRT is a temporary treatment for menopause. This means that it does not have any long-term effects on the body. So, if you abruptly stop taking Premarin, you should expect your menopausal symptoms to return.

It is not advised to stop taking HRT unless advised by a doctor.

At what age the menopause start?

Women usually have menopause at the age of 51. The average range is between the ages of 45 and 55.

What is premature menopause?

Premature menopause or ovary insufficiency occurs when a woman experiences menopause before age 40. It is rare and occurs only in 1 % of women.

What are the symptoms of menopause?

The symptoms of menopause are:

  • Hot flushes
  • Vaginal dryness
  • Insomnia and night sweats
  • Reduced libido
  • Anxiety and inability to focus
  • Issues with memory

What is HRT?

HRT is a hormone replacement therapy that effectively mitigates the symptoms of menopause, like night sweats and hot flushes. HRT may include tablets, patches, gels, and implants.

What are the risks of HRT?

Women receiving HRT may experience headaches, vaginal bleeding, and breast tenderness.

What is the active ingredient of the Premarin Tablet?

The active ingredient in the Premarin Tablets is conjugated estrogens.

For how long can I use the Premarin Tablet?

You can use Premarin Tablet for several years to ease the side effects of menopause.

How do I cope with heavy periods during menopause?

Menorrhagia, or heavy periods, is common in women between thirty and fifty. It may be due to fibroids, blood blisters, cysts or polyps in or around the uterus. Also, it may result from the changing hormone balance around the time of menopause or the process of ovaries ageing and failing. Consult your GP if you experience menorrhagia, as it is often a cause of further illness.

What treatments are available for heavy periods?

Multiple treatment options are available if your periods are severely heavy, like Cyclokapron, Ponston, Mirena Coil, or cyclical progestogen hormones.

● Headache 
● Breast tenderness/pain 
● Nausea 
● Abdominal pain 
● Painful joints 
● Tingling in  the hands or feet 
● Vaginal bleeding or discharge 
● Breakthrough bleeding
● Anxiety 
● Depression
● Mood swings 
● Dizziness 
● Weight gain/loss

Go through the patient information leaflet thoroughly before starting your treatment. The patient information may be found here.

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