Duac Once Daily

Medication features:

  • Helps overcome acne
  • Clears the infection
  • Brings back natural skin tone and texture


Available size:

30g 60g


Price £29.99

Includes free private prescriptions

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Delivery Time


Expected delivery date:

Wednesday, 13 December 2023

If you order within:


Next Day Delivery

Next Day

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UK Registered Pharmacy

UK Registered

Discreet & Confidential

Discreet &

  • Overview
  • FAQ
  • Side Effects
  • Patient Information Leaflet
  • Reviews

What is Duac Once Daily

Acne is a very common issue with an estimated 80% of people aged between 11 and 30 suffering with an outbreak of it as some point. It can be highly distressing and can affect the confidence of the sufferer as well as being extremely painful in some cases.

The powerful double action of Duac’s active ingredients can help you to overcome your acne struggles, clearing the infection from within and bringing back your natural skin tone and texture.

Can I buy Duac online?

Duac Once Daily can be purchased online only once it has been prescribed. To get a prescription, you must fill in a short medical questionnaire which allows our health experts to assess whether this treatment will be beneficial for your situation. If not you will be advised as to which treatment may be preferable based on a number of factors, including information such as your current health and any other medications you are taking or using.

Once you have received your prescription, you can purchase Duac online, and it will be sent to you by next-day delivery where possible.

How long can I take Duac for?

Duac is known to get to work within 48 hours, and results can be seen from as little as two weeks. It is important to persevere with the treatment but to discontinue use after 12 weeks to give the skin a break.

To avoid your acne coming back after you stop using the treatment, you may be advised to use a 2% to 4% benzoyl peroxide product for a minimum of a week after your stop Duac.

Other Warnings to consider

Duac’s ingredients can bleach clothing and towels, so be aware of what you put on when using it and when drying your face.

What are the side effects of Duac?

Different people will react in different ways when using a product such as Duac but the most common side effects of the gel can include:

  • dryness
  • itching
  • redness
  • mild peeling of the skin
  • a burning sensation

If you experience any major side effects, including severe redness, burning or stinging, or excessive peeling, then stop the treatment and consult with your Click Pharmacy doctor or GP.

In some rare cases, the antibiotic can get into the body’s digestive system, where it will do its job of killing all bacteria there aside from Clostridium difficile, which can trigger diarrhoea. If you experience diarrhoea, stop using the treatment and book an appointment with your doctor that day to discuss your next steps. You can book a free and confidential online appointment with the doctors at Click Pharmacy at any time.

How effective is Duac?

Duac contains two powerful active ingredients called clindamycin phosphate and benzoyl peroxide. Together they are designed to effectively treat the bacterial infection by breaking down the comedones, the black and white heads, which will, in turn, unblock the glands.

The two ingredients, when working together, are known to be highly effective in dealing with acne, with 50% of blemishes clearing up in as little two weeks in some cases where Duac is applied. It has also been shown to remove nearly double the number of blemishes than it’s closest acne-fighting competitor and 10% more by the end of the first month of use.

Why choose Duac?

Duac is a popular choice because it only needs to be applied once a day, making it an easy treatment to use. It is also preferable for anyone who does not wish to take tablets, as the skin is still getting the benefit of an antibiotic without the need to swallow a pill.

Another reason for its popularity is that together, the ingredients can remove nearly all acne bacteria on the skin, clearing it up and easing the discomfort of outbreaks in a matter of weeks. In fact, Clindamycin, the antibiotic contained in Duac, is the number one antibiotic used for clearing up acne in the UK. One major reason for this is that the other antibiotic sometimes prescribed for acne can stain teeth, whereas Clindamycin does not.

What is contained in Duac?

Duac is a gel which contains two active ingredients; an antibiotic designed to kill the bacteria causing the acne called clindamycin and an acne-fighting antiseptic called benzoyl peroxide.

How should I take Duac?

Duac is designed to be used once a day, in the evening. It is important to wash the skin with a mild cleanser before applying the gel to ensure the skin is as clean as possible.

The treatment must be applied in a thin layer to all affected areas of the skin rather than only on specific spots.

It is important to apply sparingly. If the gel is difficult to rub in, you have used too much.

How does Duac work?

Clindamycin is widely used to fight many bacteria-based infections, including Propioni bacterium acnes, the bacteria which feeds on the sebum produced within the skin’s sebaceous glands. This bacteria produce fatty acids and waste products, which begin to irritate the glands causing them to become inflamed and erupt into acne-like spots. The application of clindamycin controls the number of bacteria able to survive on the skin, thus stopping the irritation and inflammation and allowing the skin to heal.

The medication fighting alongside the antibiotic in Duac is benzoyl peroxide which is a keratolytic, a medicine designed to break down the protein forming part of the structure of the skin known as keratin. The application of this antiseptic breaks down skin cells, causing them to shed and break down the comedones, also known as blackheads and whiteheads with it. This then clears the sebaceous glands, which means fewer comedones can be formed.

Duac gets to work in as little 48 hours with the clindamycin killing bacteria which causes the acne, and then any bacteria left behind is then cleared up by the antibacterial benzoyl peroxide.

Alternative Treatments

Duac Gel is a prescription-only product. Before using it, you should try over-the-counter products first. They may be adequate for your acne. However, if they do not work, consult your GP.

One of the most popular active used to treat acne is benzoyl peroxide. You can find it in various forms, such as cleansers, gels, creams, and more. It is an OTC.

Also, if Duac Gel is unsuitable for you, then you can try other antibiotic-based acne treatments. These include oral Lymecycline and topical Zineryt. In addition to this, retinoid-based treatments work just as well. You can find them under brand names such as Differin cream and Epiduo gel.

How to store Duac Gel

You can find proper storage instructions on the leaflet that comes with Duac Gel. The most basic storage instruction is to avoid keeping it in places that are above 25°C. Discarding the gel about two months after you open it is also important. Do not use Duac Gel after the expiry date. You can find the precise expiry date, the batch number on the tube, and the carton it comes in. It may be under EXP.

Avoid discarding the gel via wastewater or your household wastebaskets. Instead, hand the expired medication to your pharmacist, as they are well-equipped to eliminate medicinal waste. Doing so will significantly help the environment.

Do I have to use Duac at night?

Applying Duac Gel at night is the most convenient option for most individuals. This is because Duac Gel is supposed to be applied to clean, dry, and make-up-free skin. Therefore, you can simply use it as part of your skincare routine – wait for the gel to dry before you apply anything on top. Note that Duac Gel can bleach pieces of clothing, so it is important to let it dry as it can bleach your pillowcases, clothes, linens or anything your face comes in contact with.

Can I wear makeup over Duac?

Yes, you can wear makeup over Duac Gel. Make sure that the gel has dried completely, and only use oil-free makeup products.

Epiduo Gel vs Duac

Duac Gel and Epiduo Gel are both acne treatments that contain benzoyl peroxide as one of their active ingredients. However, the other active ingredients vary. While Duac Gel contains the antibiotic known as macrolide antibiotic clindamycin, Epiduo Gel contains adapalene – which is commonly referred to as Differin.

Adapalene or Differin is a retinoid. It is a more potent vitamin A derivative rather than an antibiotic. Adapalene works in harmony with benzoyl peroxide to unclog pores. It reduces symptoms of acne by controlling oil production,

Epiduo and Duac Gel are used in the same way. You are supposed to apply the gel once on bare and dry skin. Just like Duac Gel, Epiduo can take some time to work. But you will experience an improvement within a month. However, if you do not see any improvement, stop using the product and consult your GP.

Duac Gel vs Differin

Differin is found under brand name adapalene, which is a human-made Vitamin C derivative. It is categorised under the retinoid class of drugs as it is relatively more robust than typical vitamin C. Since adapalene is the active ingredient in Differin, the critical difference between Differin and Duac is the active ingredients.

Even then, the two gels are topical acne treatments that work in a similar manner. Both reduce oil production and unclog the pores. However, adapalene improves acne by enhancing the turnover of skin cells. Differin also acts as an anti-inflammatory.

Apply Differn and Duac once a day on bare and dry skin. Like Duac, Differin can take a few weeks to work.

Can I buy Duac Gel over the counter?

Duac Gel is a prescription-only drug. You can not buy Duac Gel over the counter since the treatment contains the active ingredient clindamycin.

What is the active ingredient in Duac Gel?

Duac Gel contains two active ingredients, clindamycin and benzoyl peroxide. These ingredients work well together to treat symptoms of acne.

How long after using Duac Gel does it take to notice a difference?

After using Duac Gel most people begin to notice an improvement in their acne in as little as two weeks.

Who should not use Duac Gel?

You should not use Duac Gel to treat acne if you have any intestinal disorders.

Can I go out in the sun while using Duac Gel?

Using Duac Gel makes your skin more sensitive to the sun. You should try to avoid exposure to the sun. you should always wear sunscreen with an spf of at least 30.

Can I use a tanning booth and beds while using Duac Gel?

You should not use any type of tanning bed or booth when using Duac Gel to treat your acne.

Can I use other acne treating medications while using Duac Gel to treat my acne?

You should not use any other acne medications while using Duac Gel. If you feel that you need to use another product you should always consult with a GP or pharmacist before doing so.

Can my acne come back if I stop using Duac Gel?

By completing your treatment you reduce the chances of the bacterial infection coming back. However there may be other factors that determine whether or not the acne will come back.

While using Duac Gel to treat acne you may experience a number of side effects. Using a moisturising cream or lotion can help to reduce many of the side effects that this gel may cause. Common side effects include:

  • Dry skin
  • Redness
  • Burning
  • Skin peeling
  • Itching

If any of these side effects worsen, you should stop using Duac Gel and speak to a GP or pharmacist as soon as possible.


Always read the patient information leaflet before starting your treatment. The patient information can be found here.

Authored by

Last reviewed 11 April 2023

Superintendent Pharmacist GPhC No.2220953

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