Elleste Duet available in1mg, 2mg & Conti Tablets is an effective HRT for menopause. Buy Elleste Duet from Click Pharmacy today, we have a wide range of HRT availabl


6/23/2025 3:08:03 PM


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Elleste Duet

Elleste Duet is a medication used to help with symptoms experienced during menopause, like hot flashes, night sweats, and vaginal dryness.

Medication features:

  • An HRT medication 
  • Contains estradiol hemihydrate and norethisterone acetate
  • Can be used before, during and after menopause

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Expected Delivery: Tuesday

If you order within: 12h36m

Elleste Duet Prices

  • Medicine prices
  • Delivery Information
Medicine 84 Tablets
Elleste Duet 1mg £28.99
Elleste Duet 2mg £29.99

Prices include free private prescription.

Delivery charges

Orders approved by our medical team before 3pm Monday – Friday are dispatched the same day via Royal mail. All orders are sent using a tracked and signed for service. Orders are not dispatched on weekends and bank holidays.

Royal Mail 1st Class | £3.95

Delivered within 1-3 working days. Excludes bank holidays. A tracked service with signature required on delivery.

Royal Mail Special Delivery Guaranteed before 1pm | £6.95

Delivered within 1 working day before 1pm. Excludes Sundays and bank holidays. A tracked service with signature required on delivery.

Find out more about our delivery service.

Refunds and returns – Read further information on return and refunds.

  • Overview
  • Directions
  • Cautions
  • FAQ

Buy Elleste Duet Online UK

You can order Elleste Duet online in the UK from our registered pharmacy. Complete the online medical assessment to be reviewed by one of our prescribers. If approved, your medication will be dispensed by our pharmacy team for next day delivery to your address. 

About Elleste Duet

Elleste Duet is an HRT medication which can be used before, during and after menopause. It works by replacing the two female hormones, oestrogen and progesterone, whose levels drop drastically during that time. Therefore, it may be highly effective for women suffering from menopause symptoms. 

Hormone levels drop as a woman approaches menopause, bringing several uncomfortable or unpleasant symptoms such as irregular periods, vaginal dryness, chills, mood swings, reduced sex drive, night sweats, and slowed metabolism. The symptoms may be eased with hormone replacement therapy or HRT. 

Elleste Duet Summary Information

Type of medicine

Hormone replacement therapy (HRT) medication


Relieves menopause symptoms

How it works

Contains estradiol and norethisterone to balance hormones

Active Ingredient

Estradiol, Norethisterone

Drug class

HRT, unopposed oestrogens

Directions of use

Oral tablets

Available strengths

1mg , 2mg

Side effects

Common side effects include Nausea, breast tenderness, irregular bleeding, stomach cramps, headache


Store at room temperature




Not recommended, ask your doctor

The information provided in the summary table is for reference only. It is important to consult a qualified healthcare professional before starting any menopause treatment, including Elleste Duet.

How effective are the Elleste Duet tablets?

Elleste Duet is effective even at low doses to relieve post-menopausal symptoms. Depending on your situation and where you are in your menopause journey, you may take it short or long-term. The drug may also effectively prevent osteoporosis for women with a heightened risk of fractures if they cannot take any other form of prevention medication. This can occur as the bone-strengthening and protecting hormone oestrogen decreases during menopause.  

The effects of the Elleste Duet kick in relatively quickly, with many women experiencing the benefits within just a few weeks.  

What is contained in Elleste Duet tablets?

The two active ingredients in Elleste Duet are a natural form of oestrogen called estradiol hemihydrate (previously oestradiol hemihydrate) and a synthetic form of progesterone called norethisterone acetate.

The inactive ingredients are:

  • Lactose monohydrate
  • Maise starch
  • Povidone 25
  • Talc (purified)
  • Magnesium stearate

The ingredients in the film-coating material are:

  • Hydroxypropylmethylcellulose (E464)
  • Titanium dioxide (E171)
  • Macrogol 400
  • Black iron oxide (E172)

If you are allergic to the active and other ingredients, inform your doctor, and they can help you source a safe alternative treatment.

How do Elleste Duet tablets work?

As menopause approaches, the ovaries produce less oestrogen resulting in symptoms such as night sweats, irregular menstruation patterns and vaginal dryness. Estradiol replaces these lost hormones, helping to ease these issues.

For women who haven't had a hysterectomy, oestrogen causes the growth of the womb lining. If this grows without the progesterone to stop it, the result may be endometrial cancer. Progesterone (norethisterone) is in this combination treatment to combat the risk.

Lifestyle changes to improve menopause symptoms

There are various lifestyle changes that you can implement to make a difference in your menopause symptoms. Try the following:

  • Avoid consuming caffeine
  • Avoid Smoking
  • Cut back on alcohol
  • Stop eating spicy foods
  • Only wear loose and breathable items of clothing
  • Exercise regularly
  • Increase your vitamin D intake
  • Use moisturisers and lubricants for vaginal dryness

These lifestyle changes can decrease the occurrence of hot flashes and night sweats.

Elleste Solo vs Elleste Duet

The main difference between these HRTs is that Elleste Solo tablets contain only estradiol (oestrogen). On the other hand, Elleste Duet contains both estradiol and norethisterone (oestrogen and progesterone). Since the Elleste Solo tablet does not contain progesterone, it is only suitable for individuals who have had a hysterectomy or people with an intrauterine system (IUS/Mirena coil).

Elleste Duet vs Elleste Duet Conti

Elleste Duet Conti gives you a steady dose of oestrogen and progestogen daily, meaning you will not get your period every month. In contrast, Elleste Duet only has 16 days of estradiol and 12 days of combined estradiol and norethisterone. This means that Elleste Duet is ideal for women who still have a menstrual cycle, while Elleste Duet Conti is better suited for those who have not gotten a natural period for about 12 months or more.


How should I take Elleste Duet tablet?

Take one tablet daily with a drink, either with or without a meal. Take the tablet at a fixed time each day for best results. Take a missed dose within 12 hours if you remember to take it. Do not double up or take two within 12 hours of each other.

You do not need to take breaks between your packs of Elleste Duet. However, have your treatment reviewed at least once a year to ensure you are still using the best form of medication and receiving the most significant benefits from it.

For how long can I take the Elleste Duet?

You may take Elleste Duet consecutively every day. However, having this reviewed annually at least once with your GP is highly recommended.

  • For the management of menopause, patients will usually be prescribed at least 3 months of treatment.
  • In the case of premature menopause, HRT treatments such as Elleste Duet Conti are recommended until normal menopause and around 5 to 10 years after age 50.
  • Premenopausal women aged 50+ may be prescribed Elleste Duet for around 5 years to ease menopausal symptoms.

Side effects

Medications can affect every patient differently. Elleste Duet side effects are mild and short-lived as the body gets used to the new medication. However, if you develop any complications or severe problems after taking HRT medication, contact the doctor immediately or the pharmacist at Click Pharmacy.

The most common Elleste Duet side effects can include

  • Thrush
  • Painful periods
  • Problems with the menstrual cycle
  • Diarrhoea
  • Back pain
  • Stomach cramps
  • Soreness of the breasts
  • Acne
  • Rashes
  • Swelling
  • Migraines
  • Mood swings
  • Itchiness
  • Dry skin
  • Anxiety
  • Weight changes

Serious side effects are rare, but can be jaundice, allergies to the ingredients, heart attack or high blood pressure, DVT, which may manifest as a sore or swollen leg, chest pain and coughing blood. If any of these unlikely events occur, seek emergency medical help immediately.

Stop taking HRT treatment and seek medical attention immediately if you notice early signs of any of the following:

  • Blood clots – breathing difficulty, swelling of the legs and pain
  • Heart disease – chest pain extending to the neck or arm
  • Stroke – blurred vision, migraines
  • Liver disease – yellow colouration of the eyes and skin

Carefully read the patient information leaflet, which comes with your prescription for potential side effects. For any concerns or queries, book a free and confidential appointment with one of our pharmacists to discuss this. Contact your GP if the side effects do not disappear after 48 hours.

Other warnings to consider

You must let your doctor know what medications you are already taking, including herbal and over-the-counter treatments, as some medicines could hinder the HRT's effectiveness.

In some situations, HRT, such as Elleste Duet, cannot or should not be prescribed. Elleste Duet warnings include the following:

  • Increased risk of oestrogen sensitive cancer
  • Suffered from or currently suffer from breast cancer or cancer of the endometrium
  • Suffer from liver disease
  • Have ever had a blood clot or have a blood clotting disorder
  • Have suffered from DVT in the last six months
  • Experienced a stroke or a heart attack
  • Pregnant or breastfeeding
  • Have unexplained vaginal bleeding
  • Suffer from liver disease
  • Allergic to the active ingredients in Elleste Duet

If you have diabetes, the doctor may adjust your insulin for the new medication. Also, monitor your blood sugar level regularly when taking Elleste Duet. If you find any change, contact your GP as soon as possible.

Inform your GP if you plan to take HRT treatment and have ever had any of the following health complications:

  • Fibroids
  • Impaired liver function
  • Circulation problems
  • Uterine problems, including endometriosis or endometrial hyperplasia
  • Diabetes
  • Migraine
  • Increased risk of blood clots
  • Gallstones
  • Epilepsy
  • An autoimmune disorder
  • A history of severe allergic reactions
  • Asthma
  • High-fat levels in the blood
  • Fluid retention
  • High blood pressure
  • Obesity
  • Otosclerosis
  • A family history of breast cancer or another oestrogen-sensitive cancer


What are the symptoms of menopause?

The symptoms of menopause are:

  • Hot flushes
  • Vaginal dryness
  • Insomnia and night sweats
  • Reduced libido
  • Anxiety and inability to focus
  • Issues with memory

What is the difference between the two types of HRT?

Hormone Replacement Therapy can be oestrogen-only or combined with progestogen. However, oestrogen-only HRT can increase the risk of uterine cancer, so it is advised only for women who have had a hysterectomy.

Combined HRT is associated with a heightened risk of some other cancers, but only after treatment spanning many years.

Elleste Duet Reviews

How to order medications from us

Order your medication in a few clicks. Our process is easy, fast and secure.

Step 1

Short Medical Assessment

Fill out a questionnaire so our prescriber can assess if the treatment is suitable for you.

Step 2

Select Preferred Medication

Choose the medication you require from the range offered by our online pharmacy.

Step 3

Next Day

Add delivery details and complete payment process.

Price £28.99

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Available strengths:

1mg 2mg


Price £28.99

Includes free private prescriptions

In stock

2024/06/23 2024/06/24

Order before 15:00pm (Monday to Friday) for next day delivery