Evorel Sequi Patches is an effective HRT for menopause. Buy Evorel Sequi Patches from Click Pharmacy today, we have a wide range of HRT available.


5/21/2025 11:05:17 AM


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Evorel Sequi Patches

Evorel Sequi Patches help ease menopause symptoms like hot flashes, night sweats, and vaginal dryness.

Medication features:

  • Sequential hormone replacement therapy
  • Contains oestrogen and progesterone
  • Suitable for women who still have a womb

Next Day Delivery Available

UK Registered Pharmacy

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Expected Delivery: Wednesday

If you order within: 12h36m

Evorel Sequi Patches Prices

  • Medicine prices
  • Delivery Information
Medicine Quantity Price
Evorel Sequi Patches 50mcg 8 Patches £26.99
Evorel Sequi Patches 50mcg 16 Patches £49.99
Evorel Sequi Patches 50mcg 24 Patches £74.99

Delivery charges

Orders approved by our medical team before 3pm Monday – Friday are dispatched the same day via Royal mail. All orders are sent using a tracked and signed for service. Orders are not dispatched on weekends and bank holidays.

Royal Mail 1st Class | £3.95

Delivered within 1-3 working days. Excludes bank holidays. A tracked service with signature required on delivery.

Royal Mail Special Delivery Guaranteed before 1pm | £6.95

Delivered within 1 working day before 1pm. Excludes Sundays and bank holidays. A tracked service with signature required on delivery.

Find out more about our delivery service.

Refunds and returns – Read further information on return and refunds.

  • Overview
  • Directions
  • Cautions
  • FAQ

Buy Evorel Sequi Patches Online

You can order Evorel Sequi Patches online in the UK from our registered pharmacy. Complete the online medical assessment to be reviewed by one of our prescribers. If approved, your medication will be dispensed by our pharmacy team for next day delivery to your address.

About Evorel Sequi Patches

Evorel Sequi patch is a combined hormone replacement therapy (HRT) to treat symptoms of menopause. Most HRT treatments involve daily tablets. However, Evorel Sequi is a patch placed on the skin and changed twice weekly. Evorel Sequi is known as sequential hormone replacement therapy. It contains two types of patches that, over 4 weeks, release two active ingredients which imitate the female sex hormones, oestrogen and progesterone. It is an easy alternative for patients who prefer not to swallow tablets daily.

Evorel Sequi Patches are an easy way to ease the life-altering symptoms of menopause, like hot flushes, strong heartbeat, osteoporosis, dryness of the eyes, mood swings, reduced sex drive, night sweats, vaginal dryness, irritability, insomnia, and pain during sex.

Evorel Sequi Patches Summary Information

Type of medicine

Hormone replacement therapy (HRT) medication


Relieves symptoms of menopause

How it works

Contains estradiol and norethisterone to restore hormonal balance

Active Ingredient

Estradiol, Norethisterone

Directions of use

Transdermal patches applied to clean, dry skin

Available strengths

50 mcg

Side effects

Common side effects include Headache, breast pain, nausea, diarrhoea, stomach pain, painful joints


Store at room temperature away from light and moisture



The information provided in the summary table is for reference only. It is important to consult a qualified healthcare professional before starting any menopause treatment, including Evorel Sequi Patches.

Why choose the Evorel Sequi Patch?

Evorel Sequi Patch is a quick and straightforward way to receive the exact dose of hormones you require daily. In addition, it frees you from forgetting to take a tablet or worrying about applying the cream.

Evorel Sequi is a convenient alternative for patients who cannot or prefer not to swallow tablets every day. The quick and easy application means you receive the hormones you need without worrying about forgetting to take it or anyone else being affected.

What is contained in the Evorel Sequi Patch?

The active ingredients in the Evorel Sequi patch are:

  • Evorel 50 Patches- contain estradiol hemihydrate 3.2 mg
  • Evorel Conti Patches- contain estradiol hemihydrate 3.2 mg and norethisterone acetate 11.2 mg.

The inactive ingredients are: 

  • Guar gum
  • Duro-Tak 387-2287, which makes the patches stick
  • Hostaphan MN19 on the backing film.

In case of any allergic responses, consult your GP or Click pharmacy doctor before going ahead and purchasing your prescription.

How do Evorel Sequi Patches work?

Evorel Sequi patches work by restoring the hormonal balance in the body, reducing or preventing menopausal symptoms from occurring. Hormone Replacement Therapy (HRT) eases the symptoms of menopause by supplementing the levels of hormones that the body can produce naturally. 

Evorel Sequi is a continuous sequential HRT. This is because two hormones are active one after another:

● The patch supplies estradiol for two weeks.
● Then estradiol and norethisterone are provided together for the next two weeks.

Evorel Sequi patches replace the hormone oestrogen, usually released by the ovaries. However, taking an oestrogen hormone daily may cause the lining of your womb to build up and get thicker.

● It is vital to add a progestogen hormone to the oestrogen.
● This helps shed the womb’s lining and stop any problems from happening. Evorel Conti patches for weeks 3 and 4 contain this progestogen.

The shedding of the womb’s lining will probably give a withdrawal of bleeding. It will be like having a period each month. The withdrawal bleeding will start during week 4 before you finish an Evorel Sequi pack.

How long does it take for Evorel Sequi patches to work?

Everol Sequi patches begin working as soon as you apply them. However, it may take you a week or two to notice the benefits of it.

Note that it is crucial to keep in mind that the exact time it takes an individual to feel the effects of Everol Sequi patches typically varies from person to person. So if the treatment works within a week for someone else, it may be entirely different for you. But, if you have reason to believe that the patches are not working for you, you should consult your GP about possible solutions or alternative treatments.

How effective are Evorel Sequi patches?

Evorel Sequi patches are considered incredibly effective. Experts say they treat a wide range of symptoms caused by menopause effectively. This may include physical symptoms like hot flashes, night sweats as well as vaginal dryness. In addition to this, the patches help with psychological symptoms such as depression and mood swings, too.

Alternative treatments to Evorel Sequi

Inform your GP if Evorel Sequi patches are not suitable for you. There are various alternatives to these patches, such as topical creams. Your GP will help you determine the best menopausal treatment for you.

Interactions of Evorel Sequi

Do not use Evorel Sequi patches if you are on any of the following medicines:

  • Epilepsy medication (such as lamotrigine or carbamazepine)
  • Tuberculosis medication (such as rifampicin)
  • HIV medicines (such as nevirapine or ritonavir)
  • Bosentan, or medication used to reduce blood pressure in the lungs
  • St Johns Wort

How to apply Evorel Sequi Patch?

  • Always change the patch on the same days every week.
  • One patch is for three days, and the following patch is for four days.
  • Apply the Evorel Sequi Patch to dry and clean skin. Press down firmly to ensure that the patch is in place.
  • Do not place the new patch on the exact same part of the skin.
  • Evorel should not be used on or around the breasts, broken skin or under elasticated parts of clothing.

For how long can I use the Evorel Sequi Patch?

You can use Evorel Sequi Patch for several years to ease the side effects of menopause. In the UK, the average menopause age in women is 51, though some women start normal menopause as early as 45. Menopausal symptoms usually last between 4 and 5 years, so in most situations, HRT may be used during this time.

HRT must only be necessary as a relatively short-term treatment as your body adjusts to menopause. You should review your HRT with your GP at least once each year and have regular gynaecological checkups.

What are the side effects of the Evorel Sequi Patch?

Aside from the benefits of Evorel Sequi Patches, there are potential side effects which may be experienced by some women and not by others. Doctors usually recommend waiting at least 12 weeks before changing HRT so your body may get used to the effects of the hormones and balance out. After this time, most women find their side effects disappear. However, you may speak to your doctor anytime if you are concerned.

The potential side effects of the patch are

  • headache.
  • breast tenderness/pain.
  • nausea.
  • diarrhoea.
  • stomach pain.
  • painful joints.
  • tingling in the hands or feet.
  • vaginal bleeding or discharge.
  • breakthrough bleeding.
  • painful periods.
  • anxiety.
  • mood swings.
  • water retention.
  • fatigue.
  • dizziness.
  • weight gain.
  • itchiness or inflamed skin where the patch is applied.

Stop using Evorel Patch and seek medical attention immediately if you notice early signs of any of the following:

  • Blood clots – pain and swelling of the legs, difficulty breathing.
  • Stroke – sudden migraines, blurred vision.
  • Heart disease – chest pain which extends to the neck or arm.
  • Liver disease – yellow colouration of the skin or eyes.

In case you are worried about these adverse effects, or if the product affects you in any other way, stop using it immediately and talk to your GP or a pharmacist.

Other warnings to consider

HRT pose an increased risk of developing breast cancer, endometrium or ovaries. However, combined HRTs such as Evorel Sequi Patches help to lower this risk in women who have not had their wombs removed.  

Evorel Sequi Patches are not recommended for women with heart disease or a heart attack, as HRT can affect the heart and circulation.

Blood clots are likely to occur in HRT users. The risk of developing them, especially in the first year of using a treatment, may be increased in certain situations if you:

  • May have cancer which is sensitive to oestrogen (including uterine cancer)
  • Ever had breast cancer
  • Have untreated endometrial hyperplasia (an excessively thick womb lining)
  • Have recently had a heart attack or stroke
  • Suffer from a blood clotting disease or have ever had a blood clot
  • Have a history of liver disease
  • Have unexplained vaginal bleeding
  • You are allergic to the ingredients of  the patch
  • Suffer from porphyria (a rare hereditary blood disease)
  • Are pregnant or breastfeeding

Inform your GP if you plan to use Evorel Sequi Patch and have ever had any of the following health complications:

  • Impaired liver function
  • Fibroids
  • Uterine problems, including endometriosis or endometrial hyperplasia
  • High risk of blood clots
  • Circulation problems (e.g. angina, heart attack)
  • Migraine
  • Diabetes
  • Gallstones
  • Systemic lupus erythematosus
  • Fluid retention
  • Asthma
  • Epilepsy
  • High blood pressure
  • Otosclerosis (a hereditary ear disorder)
  • High-fat levels in the blood
  • History of severe allergic reactions
  • A family history of breast cancer or another oestrogen-sensitive cancer

Evorel Sequi, Pregnancy and Breastfeeding

You should not use Evorel Sequi patches if you are pregnant. Likewise, you should not use them if you have had a natural period in the last year. Additionally, avoid using the patches if you are under 50 – unless doctors advise otherwise.

Similarly, if you are breastfeeding, you should not use Evorel Sequi patches as an excess of oestrogen could be transferred to the fetus, creating health complications.

Lastly, please make sure to read all packaging and the Patient Information Leaflet before you try any new medication. In addition, you should continually update your GP regarding medicines you are taking or intend to take.

What is Osteoporosis?

The weakening of the bones due to reduced oestrogen levels is osteoporosis. It is more common in women who have reached menopause. Oestrogen from HRT may prevent osteoporosis in the short term. However, once you stop HRT, you may again experience osteoporosis.

What is the active ingredient of the Evorel Sequi Patch?

The active ingredients in the Evorel Sequi patch are estradiol hemihydrate and synthetic progesterone.

How do I cope with heavy periods during menopause?

Menorrhagia, or heavy periods, is common in women between thirty and fifty. It may be due to fibroids, blood blisters, cysts or polyps in or around the uterus. Also, it may result from the changing hormone balance around the time of menopause or the process of ovaries ageing and failing. Consult your GP if you experience menorrhagia, as it is often a cause of further illness.

Evorel Sequi Patches Reviews

How to order medications from us

Order your medication in a few clicks. Our process is easy, fast and secure.

Step 1

Short Medical Assessment

Fill out a questionnaire so our prescriber can assess if the treatment is suitable for you.

Step 2

Select Preferred Medication

Choose the medication you require from the range offered by our online pharmacy.

Step 3

Next Day

Add delivery details and complete payment process.

Price £26.99

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Price £26.99

Includes free private prescriptions

In stock

2024/05/21 2024/05/22

Order before 15:00pm (Monday to Friday) for next day delivery