Evorel Sequi Patches

Medication features:

  • Sequential hormone replacement therapy
  • Contains oestrogen and progesterone
  • Suitable for women who still have a womb


Available strengths:



Price £26.99

Includes free private prescriptions

In stock

Delivery Time


Expected delivery date:

Wednesday, 13 December 2023

If you order within:


Next Day Delivery

Next Day

Quick Assessment


UK Registered Pharmacy

UK Registered

Discreet & Confidential

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  • Overview
  • FAQ
  • Side Effects
  • Patient Information Leaflet
  • Reviews

What is Evorel Sequi Patches

Evorel Sequi patch is a combined hormone replacement therapy (HRT) to treat symptoms of menopause. Most HRT treatments involve daily tablets. However, Evorel Sequi is a patch placed on the skin and changed twice weekly. Evorel Sequi is known as sequential hormone replacement therapy. It contains two types of patches that, over 4 weeks, release two active ingredients which imitate the female sex hormones, oestrogen and progesterone. It is an easy alternative for patients who prefer not to swallow tablets daily.

Evorel Sequi Patches are an easy way to ease the life-altering symptoms of menopause, like hot flushes, strong heartbeat, osteoporosis, dryness of the eyes, mood swings, reduced sex drive, night sweats, vaginal dryness, irritability, insomnia, and pain during sex.

Why choose the Evorel Sequi Patch?

Evorel Sequi Patch is a quick and straightforward way to receive the exact dose of hormones you require daily. In addition, it frees you from forgetting to take a tablet or worrying about applying the cream.

Evorel Sequi is a convenient alternative for patients who cannot or prefer not to swallow tablets every day. The quick and easy application means you receive the hormones you need without worrying about forgetting to take it or anyone else being affected.

What is contained in the Evorel Sequi Patch?

The active ingredients in the Evorel Sequi patch are:

  • Evorel 50 Patches- contain estradiol hemihydrate 3.2 mg
  • Evorel Conti Patches- contain estradiol hemihydrate 3.2 mg and norethisterone acetate 11.2 mg.

The inactive ingredients are: 

  • Guar gum
  • Duro-Tak 387-2287, which makes the patches stick
  • Hostaphan MN19 on the backing film.

In case of any allergic responses, consult your GP or Click pharmacy doctor before going ahead and purchasing your prescription.

What dose should I choose?

Evorel Sequi Patch is an HRT for continuous use. Evorel Sequi is a patch placed on the skin and changed twice weekly. The pack consists of eight patches. Each pack contains:

  • Four Evorel 50 patches- marked CE50, containing estradiol only.
  • Four Evorel Conti Patches- marked CEN1, containing estradiol and norethisterone.

The hormones are evenly spread in the patch. They slowly pass into your body through the skin.

How should I use the Evorel Sequi Patch?

Evorel Sequi contains four Evorel 50 patches and 4 Evorel Conti patches. Apply Evorel 50 twice a week for the first 2 weeks of each 4 weeks, followed by twice-weekly changes of Evorel Conti. When you remove your fourth Evorel 50 patch, replace it with the first Evorel Conti patch. Do not leave a break between packs.

How to apply Evorel Sequi Patch?

  • Always change the patch on the same days every week.
  • One patch is for three days, and the following patch is for four days.
  • Apply the Evorel Sequi Patch to dry and clean skin. Press down firmly to ensure that the patch is in place.
  • Do not place the new patch on the exact same part of the skin.
  • Evorel should not be used on or around the breasts, broken skin or under elasticated parts of clothing.

Can I buy Evorel Sequi Patches online?

You can easily purchase Evorel Sequi Patches online via Click Pharmacy. First, you have to complete a health questionnaire. Then, our in-house doctors will assess it for the eligibility criteria. Once approved for the treatment, you may purchase it immediately. We will send your Evorel Sequi Patches out to you quickly and discreetly. You may then order again in the future without re-doing the assessment.

How effective is the Evorel Sequi Patch?

When these patches are changed twice a week, a controlled measure of the hormones is absorbed into the blood, mimicking the menstrual cycle, to reduce unpleasant menopausal symptoms.

Evorel Sequi patch is a combined sequential treatment for the symptoms of menopause. It is only suitable for women who still have a womb. It is also ideal for women who have had menopause (postmenopausal) or are around the time of menopause (perimenopausal).

It prevents osteoporosis (fragile bones) in women who have had menopause and are most likely to have bone problems.

How do Evorel Sequi Patches work?

Evorel Sequi patches work by restoring the hormonal balance in the body, reducing or preventing menopausal symptoms from occurring. Hormone Replacement Therapy (HRT) eases the symptoms of menopause by supplementing the levels of hormones that the body can produce naturally. 

Evorel Sequi is a continuous sequential HRT. This is because two hormones are active one after another:

● The patch supplies estradiol for two weeks.
● Then estradiol and norethisterone are provided together for the next two weeks.

Evorel Sequi patches replace the hormone oestrogen, usually released by the ovaries. However, taking an oestrogen hormone daily may cause the lining of your womb to build up and get thicker.

● It is vital to add a progestogen hormone to the oestrogen.
● This helps shed the womb’s lining and stop any problems from happening. Evorel Conti patches for weeks 3 and 4 contain this progestogen.

The shedding of the womb’s lining will probably give a withdrawal of bleeding. It will be like having a period each month. The withdrawal bleeding will start during week 4 before you finish an Evorel Sequi pack.

For how long can I use the Evorel Sequi Patch?

You can use Evorel Sequi Patch for several years to ease the side effects of menopause. In the UK, the average menopause age in women is 51, though some women start normal menopause as early as 45. Menopausal symptoms usually last between 4 and 5 years, so in most situations, HRT may be used during this time.

HRT must only be necessary as a relatively short-term treatment as your body adjusts to menopause. You should review your HRT with your GP at least once each year and have regular gynaecological checkups.

What are the side effects of the Evorel Sequi Patch?

Aside from the benefits of Evorel Sequi Patches, there are potential side effects which may be experienced by some women and not by others. Doctors usually recommend waiting at least 12 weeks before changing HRT so your body may get used to the effects of the hormones and balance out. After this time, most women find their side effects disappear. However, you may speak to your doctor anytime if you are concerned.

The potential side effects of the patch are headache, breast tenderness/pain, nausea, diarrhoea, stomach pain, painful joints, tingling in the hands or feet, vaginal bleeding or discharge, breakthrough bleeding, painful periods, anxiety, mood swings, water retention, fatigue, dizziness, weight gain, itchiness or inflamed skin where the patch is applied.

Stop using Evorel Patch and seek medical attention immediately if you notice early signs of any of the following:

  • Blood clots – pain and swelling of the legs, difficulty breathing.
  • Stroke – sudden migraines, blurred vision.
  • Heart disease – chest pain which extends to the neck or arm.
  • Liver disease – yellow colouration of the skin or eyes.

In case you are worried about these adverse effects, or if the product affects you in any other way, stop using it immediately and talk to your GP or a pharmacist.

Other Warnings to consider

HRT pose an increased risk of developing breast cancer, endometrium or ovaries. However, combined HRTs such as Evorel Sequi Patches help to lower this risk in women who have not had their wombs removed.  

Evorel Sequi Patches are not recommended for women with heart disease or a heart attack, as HRT can affect the heart and circulation.

Blood clots are likely to occur in HRT users. The risk of developing them, especially in the first year of using a treatment, may be increased in certain situations if you:

● May have cancer which is sensitive to oestrogen (including uterine cancer)
● Ever had breast cancer
● Have untreated endometrial hyperplasia (an excessively thick womb lining)
● Have recently had a heart attack or stroke
● Suffer from a blood clotting disease or have ever had a blood clot
● Have a history of liver disease
● Have unexplained vaginal bleeding
● You are allergic to the ingredients of  the patch
● Suffer from porphyria (a rare hereditary blood disease)
● Are pregnant or breastfeeding

Inform your GP if you plan to use Evorel Sequi Patch and have ever had any of the following health complications:

● Impaired liver function
● Fibroids
● Uterine problems, including endometriosis or endometrial hyperplasia
● High risk of blood clots
● Circulation problems (e.g. angina, heart attack)
● Migraine
● Diabetes
● Gallstones
● Systemic lupus erythematosus
● Fluid retention
● Asthma
● Epilepsy
● High blood pressure
● Otosclerosis (a hereditary ear disorder)
● High-fat levels in the blood
● History of severe allergic reactions
● A family history of breast cancer or another oestrogen-sensitive cancer

What causes Menopause?

When the oestrogen levels in a woman's body begin to drop, it indicates menopause. It is a normal part of ageing that generally occurs during the ages of 45 and 55. The low levels of oestrogen are responsible for the negative symptoms that occur during the menopausal period.

Everol Sequi patches alleviate and control the symptoms of menopause by balancing the levels of oestrogen in the body. The patches contain synthetic versions of the hormones oestrogen as well as progesterone. This combination helps the body maintain the normal levels of the female hormone.

How long does it take for Evorel Sequi patches to work?

Everol Sequi patches begin working as soon as you apply them. However, it may take you a week or two to notice the benefits of it.

Note that it is crucial to keep in mind that the exact time it takes an individual to feel the effects of Everol Sequi patches typically varies from person to person. So if the treatment works within a week for someone else, it may be entirely different for you. But, if you have reason to believe that the patches are not working for you, you should consult your GP about possible solutions or alternative treatments.

How effective are Evorel Sequi patches?

Evorel Sequi patches are considered incredibly effective. Experts say they treat a wide range of symptoms caused by menopause effectively. This may include physical symptoms like hot flashes, night sweats as well as vaginal dryness. In addition to this, the patches help with psychological symptoms such as depression and mood swings, too.

Alternative treatments to Evorel Sequi

Inform your GP if Evorel Sequi patches are not suitable for you. There are various alternatives to these patches, such as topical creams. Your GP will help you determine the best menopausal treatment for you.

Do HRT patches make you gain weight?

Sometimes. There are a few HRT products that can result in weight gain as it may be a side effect of the products. You may gain weight while using HRT patches; however, the effect varies for most. Weight gain or weight loss can also be a symptom of menopause.

Can I delay a period on Evorel Sequi?

No. Norethisterone is typically used to delay periods. Evorel Sequi patches contain oestrogen and progesterone, which are different. It is a continuous sequential HRT.

However, note that a continuous sequential HRT will give a ‘withdrawal bleed’ during its use. It is similar to a period every month. It occurs around the fourth week of the patches.

Interactions of Evorel Sequi

Do not use Evorel Sequi patches if you are on any of the following medicines:

  • Epilepsy medication (such as lamotrigine or carbamazepine)
  • Tuberculosis medication (such as rifampicin)
  • HIV medicines (such as nevirapine or ritonavir)
  • Bosentan, or medication used to reduce blood pressure in the lungs
  • St Johns Wort

Evorel Sequi, Pregnancy and Breastfeeding

You should not use Evorel Sequi patches if you are pregnant. Likewise, you should not use them if you have had a natural period in the last year. Additionally, avoid using the patches if you are under 50 – unless doctors advise otherwise.

Similarly, if you are breastfeeding, you should not use Evorel Sequi patches as an excess of oestrogen could be transferred to the fetus, creating health complications.

Lastly, please make sure to read all packaging and the Patient Information Leaflet before you try any new medication. In addition, you should continually update your GP regarding medicines you are taking or intend to take.

What is HRT?

HRT is a hormone replacement therapy that effectively mitigates the symptoms of menopause, like night sweats and hot flushes. HRT include tablets, patches, gels, and implants.

What are the risks of HRT?

Women receiving HRT may experience headaches, vaginal bleeding, and breast tenderness.

What is Osteoporosis?

The weakening of the bones due to reduced oestrogen levels is osteoporosis. It is more common in women who have reached menopause. Oestrogen from HRT may prevent osteoporosis in the short term. However, once you stop HRT, you may again experience osteoporosis.

What is the active ingredient of the Evorel Sequi Patch?

The active ingredients in the Evorel Sequi patch are estradiol hemihydrate and synthetic progesterone.

How do I cope with heavy periods during menopause?

Menorrhagia, or heavy periods, is common in women between thirty and fifty. It may be due to fibroids, blood blisters, cysts or polyps in or around the uterus. Also, it may result from the changing hormone balance around the time of menopause or the process of ovaries ageing and failing. Consult your GP if you experience menorrhagia, as it is often a cause of further illness.

What causes vaginal dryness?

Vaginal tissues become thin and dry as a result of decreased oestrogen levels. This may cause discomfort and sometimes pain during sexual activity.

● Breast tenderness/pain 
● Headache 
● Nausea 
● Stomach pain 
● Painful joints
● Diarrhoea 
● Tingling in  the hands or feet 
● Breakthrough bleeding
● Vaginal bleeding or discharge
● Anxiety 
● Water retention
● Mood swings 
● Fatigue 
● Weight gain
● Dizziness 
● Itchiness or inflamed skin where the patch is applied

Go through the patient information leaflet thoroughly before starting your treatment. The patient information can be found here.

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