Mysimba is a prescription-only medication for weigh loss. Buy Mysimba online today from Click Pharmacy.


7/17/2025 8:36:29 PM



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Mysimba Tablets

Mysimba is a prescription medicine that helps adults who are overweight or obese lose weight.

Medication features:

Weight loss treatment for adults

Daily use prolonged-release tablets

Contains Naltrexone and Bupropion

Next Day Delivery Available

UK Registered Pharmacy

Price Match Guarantee

Expected Delivery: Friday

If you order within: 12h36m

Mysimba Prices

  • Medicine prices
  • Delivery Information
Medicine Quantity Price
Mysimba 8 mg/90 mg 1 Month (112 Tablets) £109.99
Mysimba 8 mg/90 mg 2 Months (224 Tablets) £209.99
Mysimba 8 mg/90 mg 3 Months (336 Tablets) £299.99

Delivery charges

Orders approved by our medical team before 3pm Monday – Friday are dispatched the same day via Royal mail. All orders are sent using a tracked and signed for service. Orders are not dispatched on weekends and bank holidays.

Royal Mail 1st Class | £3.95

Delivered within 1-3 working days. Excludes bank holidays. A tracked service with signature required on delivery.

Royal Mail Special Delivery Guaranteed before 1pm | £6.95

Delivered within 1 working day before 1pm. Excludes Sundays and bank holidays. A tracked service with signature required on delivery.

Find out more about our delivery service.

Refunds and returns – Read further information on return and refunds.

  • Overview
  • Directions
  • Cautions

Buy Mysimba Online UK

You can order Mysimba online in the UK from our registered pharmacy. Complete the online medical assessment to be reviewed by one of our prescribers. If approved, your medication will be dispensed by our pharmacy team for next day delivery to your address. 

About Mysimba

Mysimba is a prescription weight loss treatment for obese people with a BMI of 30 or more or those who are overweight and have health complications, such as high blood pressure, diabetes, and extremely high-fat levels in the blood. For best results, it should be combined with a reduced-calorie diet and excercise.

Mysimba Summary Information

Type of medicine

Weight loss medication


Aids weight loss in adults who are obese or overweight

How it works

Combination of naltrexone and bupropion, reduces appetite and food cravings

Active Ingredient

Naltrexone, Bupropion

Directions of use

Oral tablets, taken twice daily with food

Available strengths

8 mg/90 mg

Side effects

Common side effects include sleeping problems, stress and agitation, headaches, constipation, stomach pain, nausea.



The information provided in the summary table is for reference only. It is important to consult a qualified healthcare professional before starting any weight loss treatment, including Mysimba.

How does Mysimba work?

Mysimba features a combination of two active ingredients, namely bupropion hydrochloride and naltrexone hydrochloride. Bupropion helps you feel less hungry by making you satisfied with less food. Naltrexone in the Mysimba weight loss tablets, helps curb food cravings reducing your desire to eat. 

The two ingredients of Mysimba help patients curb their appetite and control the size of the food portions. Using Mysimba tablets also boosts energy, so they stay active and follow a healthy and controlled diet to lessen their body weight.

Name Jana Abelovska
Role Superintendent Pharmacist
GPhc Number 2220953


Mysimba Dosage instructions

When starting any new medication, you should always seek the advice of your doctor. When you take Mysimba, your dose will be gradually increased over a four-week period until you reach the maintenance dose. To get the most out of Mysimba, it's important to carefully follow the dosage instructions:

  • Week 1: Take ONE tablet in the morning for 7 days
  • Week 2: Take ONE tablet in the morning and ONE tablet in the evening for 7 days
  • Week 3: Take TWO tablets in the morning and ONE in the evening for 7 days
  • Week 4: Take TWO tablets in the morning and TWO tablets in the evening for 7 days 

You should never exceed the maximum dose of 4 tablets (2 in the morning and 2 in the evening) in a day. If you haven't lost at least 5% of your body weight after 16 weeks of treatment, you should consider whether to continue with Mysimba. 

You should swallow your tablet with a full glass of water, with or immediately after a meal. Do not break, crush, or split the tablets.

Side effects

Like any other drug, Mysimba can cause side effects that you don't want. Some of these side effects can be more severe, which could mean that the treatment has to be stopped.

Some common side effect include:

  • Sleeping problems
  • Stress and agitation
  • Headaches 
  • Constipation
  • Stomach pain
  • Nausea
  • Pain in joints and muscles

Uncommon side effects include:

  • Allergic reactions (like a rash or an itchy skin condition)
  • Depression, irritability, and more energy
  • Tinnitus, dizziness, and vertigo
  • Feeling tired, having trouble focusing, and not having enough energy
  • Heart palpitations, hot flashes, and sweating a lot
  • Pain in the chest
  • Diarrhoea
  • Changes in taste, dry mouth, and toothaches
  • Ejaculation that is late
  • Feeling hot and cold
  • Loss of hair

Very rare side effects include:

  • Athlete's foot
  • Swollen glands in the groyne, armpit, or neck
  • Strange dreams and nightmares
  • Nervousness, feeling disoriented, tense, irritable, having mood swings, hallucinations, confusion, severe paranoia, and feeling very suspicious
  • Problems with balance
  • Loss of memory and mental problems
  • Almost passing out
  • Getting motion sick
  • Pain or discomfort in the ears
  • Having trouble seeing, blurred vision, eye irritation, pain, or swelling, and being more sensitive to light
  • Pain in the nose, stuffy nose, runny nose, sneezing, and sinus problems
  • Pain in the throat, more mucus being coughed up, trouble breathing, problems with the voice, coughing, and yawning
  • Blood pressure that changes or goes up
  • Pain in the middle of the stomach
  • Uncontrollable burps
  • Swollen lips
  • A hernia
  • Having gas (flatulence), haemorrhoids, ulcers or cavities
  • Pain and swelling in the gallbladder
  • Back pain that happens when the disc between two bones (vertebra) bulges out
  • Period problems, vaginal bleeding, and dryness in the vulva and vagina
  • Having trouble getting or keeping an erection
  • Having strange feelings or being weak
  • Feeling thirsty and hot
  • Being cold in the limbs (hands, feet)
  • More creatinine in the blood, which means the kidneys aren't working as well.
  • More bilirubin and liver enzymes, liver problems, and hepatitis
  • Lessened haemoglobin, which means fewer red blood cells.

Some people who take Mysimba may also experience other rare or very rare side effects. To learn more about all of these side effects, always read the Patient Information Leaflet.

Who should not take Mysimba?

You should not take Mysimba if the following apply to you: 

  • You are breastfeeding, trying to get pregnant, or are already pregnant
  • You are younger than 18 or older than 75
  • You are allergic to any of the ingredients in Mysimba or are taking any medicines that contain any of the active ingredients in Mysimba
  • You suffer from severe liver disease, end-stage renal disease, high blood pressure that can't be controlled, a history of seizures or fits, a brain tumour, opioid dependence, acute alcohol, opioid, or benzodiazepine withdrawal, bipolar disorder, bulimia, or anorexia nervosa, or a history of any of these conditions
  • If you are on monoamine oxidase inhibitors (MOI), you must wait at least 14 days after stopping your MOI before starting Mysimba.
  • If you are on any opiates or medicines that contain opiates (like morphine, codeine, cough syrups with dextromethorphan, or methadone), you need to wait at least 7–10 days before starting Mysimba.

Mysimba Reviews

How to order medications from us

Order your medication in a few clicks. Our process is easy, fast and secure.

Step 1

Short Medical Assessment

Fill out a questionnaire so our prescriber can assess if the treatment is suitable for you.

Step 2

Select Preferred Medication

Choose the medication you require from the range offered by our online pharmacy.

Step 3

Next Day

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Price £109.99

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Available strengths:

8 mg/90 mg


Price £87.99

Includes free private prescriptions

In stock

2024/07/17 2024/07/18

Order before 15:00pm (Monday to Friday) for next day delivery