Medication features:

  • Comes in the form of a gel
  • Contains the highest concentrate of the retinoid adapalene
  • Decreases inflammation of the skin


Available size:



Price £33.00

Includes free private prescriptions

In stock

Delivery Time


Expected delivery date:

Wednesday, 13 December 2023

If you order within:


Next Day Delivery

Next Day

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UK Registered Pharmacy

UK Registered

Discreet & Confidential

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  • Overview
  • FAQ
  • Side Effects
  • Patient Information Leaflet
  • Reviews

What is Epiduo

There is a misinformed belief that it is best to leave acne alone and let it run its course. The top experts on this skin infection know that this is not the best course of action though, because without treatment scarring and dark spots can develop on the skin as the acne clears.

Although most people associate acne with hormonal teenagers, it can develop at any stage in life with later onset acne developing in a person’s thirties, forties or even fifties and beyond. It can be a highly distressing ailment to live with and it can knock a person’s self-esteem dramatically. In fact, aside from decreasing the risk of scarring, one of the best reasons for going ahead with a treatment such as Epiduo is that it can help to boost a patient’s self confidence as the gel works deep down within the skin helping to stop acne from developing.

How does Epiduo work

The topical retinoid in the gel, adapalene, normalises the development of the skin cells whilst preventing the pores from blocking and promoting the renewal of skin cells.

Benzoyl peroxide is an antibacterial which kills the bacteria on the skin, which case outbreaks. Alongside this, it softens the outermost layer of skin, resulting in a peeling effect helping to renew skin cells. Together they reduce inflammation and decrease the development of new spots, as well as help to stop scarring.

Why choose Epiduo?

Epiduo is an easy-to-use prescriptive medication which needs only to be used once a day. This is a huge benefit to anyone who wants something simple to use yet powerful. It not only clears inflammation, but it also helps to prevent outbreaks from recurring. It can also be used in patients as young as 9.

It is ideal for anyone looking for a product which can sit neatly into a normal daily skincare routine, and as it does not contain an antibiotic, then if necessary, you can take it alongside secondary oral medication though this should be discussed with your doctor before going ahead.

Another benefit to choosing Epiduo is that you can use the cream under your make-up without an issue, making sure to choose an oil-free and non-comedogenic product.

How effective is Epiduo?

Epiduo gel is a treatment for patients of nine years of age and onwards and contains the highest concentrate of the retinoid adapalene, which decreases inflammation of the skin. Aside from its ability to help reduce flare-ups, it’s specially selected mix of active ingredients is also designed to help the skin to renew itself and ease scarring.

The two active ingredients found in Epiduo have been proven to work more effectively together than separately, so you not only get better results than you would if using one or the other alone, you also have the convenience of only needing to use one product to get the benefit.

Can I buy Epiduo

Epiduo is a powerful, topical treatment for acne vulgaris which requires a prescription before a patient can purchase it. You are able to get Epiduo without seeing your GP by filling in a medical health questionnaire, after which a doctor from Click Pharmacy will assess your answers. They will confirm that this is the most appropriate form of treatment for your acne issues, and once you have received your prescription, you can purchase your medication online. It will be posted out to you by next-day delivery where available.

If Epiduo is not found to be the best treatment, you can have a free and confidential online appointment to discuss other options.

What is contained in Epiduo?

Every 1-gram dose of Epiduo gel contains 1mg of adapalene which assists the skin with its renewal process and unclogs pores, and 25mg of benzoyl peroxide, which, as an antibacterial, kills spot-causing bacteria.

The product’s inactive ingredients include:

  • disodium edetate
  • copolymer of acrylamide and sodium acryloyldimethyltaurate
  • poloxamer 124
  • purified water
  • docusate sodium
  • glycerol Isohexadecane
  • polysorbate 80
  • propylene glycol (E1520)
  • sorbitan oleate

How should I take Epiduo?

Epiduo is for topical use to be used once daily. Patients must apply the gel as a thin film over the areas of the face where acne vulgaris is present. It is recommended you use a pea-sized amount for each area, e.g. chin, each cheek and forehead making sure to avoid the eyes and lips. It can also be used on the chest and back.

It is best to use the product at the same time every day, but it does not matter whether you choose morning or night, ensuring you properly cleanse the skin and allowing the skin to completely dry before application. The most important thing to remember when using Epiduo is to use it as directed by your doctor and to bear in mind that using more will not speed up the healing process.

How long can I take Epiduo for?

As long as you stick to the recommended usage of a pea-sized amount of gel per affected area, then a single prescription should last up to around 3 months. Your GP or Click Pharmacy doctor will be able to recommend how long to use Epiduo for, and your results will be reviewed after the first round of use. If you have noticed a considerable difference from Epiduo and your doctor agrees, then you can order repeat prescriptions from Click Pharmacy as required.

What are the side effects of Epiduo?

There can be a few potential side effects with Epiduo due to the two active ingredients, adapalene and benzoyl peroxide.

The most common side effects include:

  • erythema (reddening) of the skin
  • a burning or stinging sensation
  • peeling
  • warm skin

In some cases, your body will naturally adjust to the products as the skin becomes used to it over time, and as such, side effects such as redness may ease and will not require medical attention.

With more severe reactions such as swelling and itching of the face, tongue or throat, severe dizziness or trouble breathing, it is vital you seek immediate medical attention.

Other Warnings to consider

Many medications can interact with one another including those bought over the counter. As such, it is crucial you discuss all other medications or drugs you are using prior to using Epiduo in case they prevent it from working effectively or causing a negative reaction.

It is not recommended to use Epiduo when pregnant, and it is not known if the product can be excreted into breastmilk; it has been found to be excreted into the breast milk of animals during studies, though. If this could be an issue for you, then speak to your GP or Click Pharmacy doctor about your concerns and to discuss other possible acne treatments.

The product benzoyl peroxide contained in Epiduo acts like a bleach on fabric, and as such, it is wise to ensure you wash your hands well after use and be careful when getting dressed or with bedding after application.

Avoid spending too long in sunlight or UV light, and wear sunblock or UV protective clothing over any other affected areas such as the back. This is due to the fact that Epiduo can cause skin sensitivity to sunlight.

Is Epiduo suitable for me?

If you have an abnormal amount of acne, or if other parts of your body are covered with acne, then Epiduo Cream or Gel may not be suitable for you. Similarly, it may not be the best option for you if you are simultaneously using some other acne treatment.

Remember that it is crucial to inform your GP if you are taking any other medicines, either from your pharmacist or purchased without a prescription. Epiduo may not be suitable or must be used cautiously if you take other treatments, such as other medicines or creams for acne. In particular, if you are using medications or ointments containing vitamin A derivatives, such as Isotrex. Do not use Epiduo if you are allergic to any of the active ingredients.

Epiduo Gel is the best option for those with dry and fair skin. If required, it can be used on the chest, back, and face.

Can I wear makeup over Epiduo?

Yes. However, apply Epiduo on a bare and dry face. Then, apply non-greasy, oil-free, and non-comedogenic makeup on top.

Can I use Epiduo at night?

Yes. In fact, it is the most convenient option for you. Epiduo gel or cream should be applied to completely clean, dry, and make-up-free skin. Putting it on at night before your skincare routine is the easiest thing to do. However, make sure that the product fully dries down before you apply anything on top. In addition to this, letting it dry will prevent the product from transferring to your clothes, pillowcases, or linens.

Alternative treatments

Before using Epiduo Gel or any prescription treatment, give over-the-counter products a chance. Such OTC products may work best for you; however, if they do not, try Epiduo or other prescription-only treatments.

In general, benzoyl peroxide treatments are ideal for acne spots, zits, and scarring. You can purchase treatments containing this active ingredient over the counter at a pharmacy. For instance, Acnecide gel contains benzoyl peroxide. You can find this particular ingredient in facewashes, cleansers, spot treatments, creams, gels, and more.

You can use other antibiotic-based acne treatments if over-the-counter treatments do not work. For instance, oral Lymecycline and topical Zineryt are commonly used. You can also try retinoid-based treatments such as Differin cream or gel.

Can I Purchase Epiduo Gel Over The Counter?

No, you can not buy Epiduo Gel over the counter in the UK since it is a prescription-only treatment. However, before you are issued an Epiduo Gel prescription, a medical professional will assess your condition and determine whether it suits you. This can happen in person or with the help of a quick online consultation.

For a quick and convenient prescription for Epiduo Gel, go to our website. We offer a free and easy consultation for Epiduo Gel. to allow you to buy Epiduo Topical Gel online. After completing a questionnaire and confirming your suitability for the treatment, we will dispense the gel and deliver it to you via our next-day delivery service.

What is the active ingredient in Epiduo Gel?

The active ingredient in Epiduo Gel is benzoyl peroxide. This ingredient is effective at killing bacteria on the surface of the skin.

How long does Epiduo Gel take to work?

Epiduo Gel normally takes around 4 weeks to begin improving ons skin. Howeer this may differ depending on the severity of one's acne.

Does using Epiduo Gel affect my exposure to sunlight?

After using Epiduo Gel you should try to avoid exposure to sunlight. You should always wear sunscreen with an spf of at least 30.

Can I use artificial tans while using Epiduo Gel?

You should not use artificial tans or tanning beds while using Epiduo Gel. Doing so may result in severe skin problems.

What if I use too much Epiduo Gel?

You should refrain from using more Epiduo Gel than needed as it may irritate your skin. If you accidentally apply too much you should wash off any excess using lukewarm water.

Can pregnant or breastfeeding women use Epiduo Gel?

EpiduoGel is usually safe to use for pregnant and breastfeeding women. However you should consult with a GP, pharmacist, or midwife before doing so.

Can I use other acne products while using Epiduo Gel?

You should refrain from using other skincare products other than a mild cleaner and moisturiser while using Epiduo Gel.

After using Epiduo Gel you may experience a number of side effects. Most of these side effects are positive signs that indicate Epiduo Gel is treating your acne. Common side effects and how to overcome symptoms include:

  • Dry skin: regularly apply an oil free lip balm or moisturiser and drink lots of water to ensure skin does not lack hydration.
  • Peeling skin: stop using Epiduo Gel for a few days until irritation goes away.
  • Burning like sensation: try using Epiduo Gel less frequently, for example only once a day rather than twice.

Always read the patient information leaflet before starting your treatment. The patient information can be found here.

Authored by

Last reviewed 11 April 2023

Superintendent Pharmacist GPhC No.2220953

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