Epiduo Gel is a dual action antibiotic and benzoyl peroxide acne treatment available online from Click Pharmacy. Buy Epiduo safely and securely from Click Pharmacy t


5/21/2025 10:41:06 AM


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Epiduo 0.1%/2.5% Gel

Epiduo is a topical acne treatment containing adapalene and benzoyl peroxide. It helps unclog pores and reduce inflammation associated with acne vulgaris.

Medication features:

  • Comes in the form of a gel
  • Contains the highest concentrate of the retinoid adapalene
  • Decreases inflammation of the skin

Next Day Delivery Available

UK Registered Pharmacy

Price Match Guarantee

Expected Delivery: Wednesday

If you order within: 12h36m

Epiduo Prices

  • Medicine prices
  • Delivery Information
Medicine Quantity Price
Epiduo 45g 1 Epiduo 0.1%/2.5% Gel £33.00
Epiduo 45g 2 Epiduo 0.1%/2.5% Gel £62.00
Epiduo 45g 3 Epiduo 0.1%/2.5% Gel £87.00

Delivery charges

Orders approved by our medical team before 3pm Monday – Friday are dispatched the same day via Royal mail. All orders are sent using a tracked and signed for service. Orders are not dispatched on weekends and bank holidays.

Royal Mail 1st Class | £3.95

Delivered within 1-3 working days. Excludes bank holidays. A tracked service with signature required on delivery.

Royal Mail Special Delivery Guaranteed before 1pm | £6.95

Delivered within 1 working day before 1pm. Excludes Sundays and bank holidays. A tracked service with signature required on delivery.

Find out more about our delivery service.

Refunds and returns – Read further information on return and refunds.

  • Overview
  • Directions
  • Cautions
  • FAQ

Buy Epiduo Gel Online

You can order Epiduo online in the UK from our registered pharmacy. Complete the online medical assessment to be reviewed by one of our prescribers. If approved, your medication will be dispensed by our pharmacy team for next day delivery to your address. 

About Epiduo Gel

Epiduo is an effective prescription medication to treat acne. Acne can be a highly distressing ailment to live with and it can knock a person’s self-esteem dramatically. In fact, aside from decreasing the risk of scarring, one of the best reasons for going ahead with a treatment such as Epiduo is that it can help to boost a persons self confidence as the gel works deep down within the skin helping to stop acne from developing.

Epiduo Summary Information

Type of medicine

Acne treatment


Treats acne vulgaris

How it works

Helps unclog pores and reduce inflammation

Active Ingredient


Directions of use

Apply a thin layer to affected areas once daily

Available strengths


Side effects

Common side effects include Skin irritation, dryness, redness, burning or stinging sensation, peeling, warm skin



The information provided in the summary table is for reference only. It is important to consult a qualified healthcare professional before starting any acne treatment, including Epiduo.

How does Epiduo work

The topical retinoid in the gel, adapalene, normalises the development of the skin cells whilst preventing the pores from blocking and promoting the renewal of skin cells.

Benzoyl peroxide is an antibacterial which kills the bacteria on the skin, which case outbreaks. Alongside this, it softens the outermost layer of skin, resulting in a peeling effect helping to renew skin cells. Together they reduce inflammation and decrease the development of new spots, as well as help to stop scarring.

How effective is Epiduo?

Epiduo gel is a treatment for patients of nine years of age and onwards and contains the highest concentrate of the retinoid adapalene, which decreases inflammation of the skin. Aside from its ability to help reduce flare-ups, it’s specially selected mix of active ingredients is also designed to help the skin to renew itself and ease scarring.

The two active ingredients found in Epiduo have been proven to work more effectively together than separately, so you not only get better results than you would if using one or the other alone, you also have the convenience of only needing to use one product to get the benefit.

What is contained in Epiduo?

Every 1-gram dose of Epiduo gel contains 1mg of adapalene which assists the skin with its renewal process and unclogs pores, and 25mg of benzoyl peroxide, which, as an antibacterial, kills spot-causing bacteria.

The product’s inactive ingredients include:

  • disodium edetate
  • copolymer of acrylamide and sodium acryloyldimethyltaurate
  • poloxamer 124
  • purified water
  • docusate sodium
  • glycerol Isohexadecane
  • polysorbate 80
  • propylene glycol (E1520)
  • sorbitan oleate

Alternative treatments

Before using Epiduo Gel or any prescription treatment, give over-the-counter products a chance. Such OTC products may work best for you; however, if they do not, try Epiduo or other prescription-only treatments.

In general, benzoyl peroxide treatments are ideal for acne spots, zits, and scarring. You can purchase treatments containing this active ingredient over the counter at a pharmacy. For instance, Acnecide gel contains benzoyl peroxide. You can find this particular ingredient in facewashes, cleansers, spot treatments, creams, gels, and more.

You can use other antibiotic-based acne treatments if over-the-counter treatments do not work. For instance, oral Lymecycline and topical Zineryt are commonly used. You can also try retinoid-based treatments such as Differin cream or gel.

Name Jana Abelovska
Role Superintendent Pharmacist
GPhc Number 2220953

How should I take Epiduo?

Epiduo is for topical use to be used once daily. Patients must apply the gel as a thin film over the areas of the face where acne vulgaris is present. It is recommended you use a pea-sized amount for each area, e.g. chin, each cheek and forehead making sure to avoid the eyes and lips. It can also be used on the chest and back.

It is best to use the product at the same time every day, but it does not matter whether you choose morning or night, ensuring you properly cleanse the skin and allowing the skin to completely dry before application. The most important thing to remember when using Epiduo is to use it as directed by your doctor and to bear in mind that using more will not speed up the healing process.

How long can I take Epiduo for?

As long as you stick to the recommended usage of a pea-sized amount of gel per affected area, then a single prescription should last up to around 3 months. Your GP or Click Pharmacy doctor will be able to recommend how long to use Epiduo for, and your results will be reviewed after the first round of use. If you have noticed a considerable difference from Epiduo and your doctor agrees, then you can order repeat prescriptions from Click Pharmacy as required.

What are the side effects of Epiduo?

There can be a few potential side effects with Epiduo due to the two active ingredients, adapalene and benzoyl peroxide.

The most common side effects include:

  • erythema (reddening) of the skin
  • a burning or stinging sensation
  • peeling
  • warm skin

In some cases, your body will naturally adjust to the products as the skin becomes used to it over time, and as such, side effects such as redness may ease and will not require medical attention.

With more severe reactions such as swelling and itching of the face, tongue or throat, severe dizziness or trouble breathing, it is vital you seek immediate medical attention.

Other warnings to consider

Many medications can interact with one another including those bought over the counter. As such, it is crucial you discuss all other medications or drugs you are using prior to using Epiduo in case they prevent it from working effectively or causing a negative reaction.

It is not recommended to use Epiduo when pregnant, and it is not known if the product can be excreted into breastmilk; it has been found to be excreted into the breast milk of animals during studies, though. If this could be an issue for you, then speak to your GP or Click Pharmacy doctor about your concerns and to discuss other possible acne treatments.

The product benzoyl peroxide contained in Epiduo acts like a bleach on fabric, and as such, it is wise to ensure you wash your hands well after use and be careful when getting dressed or with bedding after application.

Avoid spending too long in sunlight or UV light, and wear sunblock or UV protective clothing over any other affected areas such as the back. This is due to the fact that Epiduo can cause skin sensitivity to sunlight.

What if I use too much Epiduo Gel?

You should refrain from using more Epiduo Gel than needed as it may irritate your skin. If you accidentally apply too much you should wash off any excess using lukewarm water.

Can pregnant or breastfeeding women use Epiduo Gel?

EpiduoGel is usually safe to use for pregnant and breastfeeding women. However you should consult with a GP, pharmacist, or midwife before doing so.

Can I use other acne products while using Epiduo Gel?

You should refrain from using other skincare products other than a mild cleaner and moisturiser while using Epiduo Gel.

Epiduo Reviews

How to order medications from us

Order your medication in a few clicks. Our process is easy, fast and secure.

Step 1

Short Medical Assessment

Fill out a questionnaire so our prescriber can assess if the treatment is suitable for you.

Step 2

Select Preferred Medication

Choose the medication you require from the range offered by our online pharmacy.

Step 3

Next Day

Add delivery details and complete payment process.

Price £33.00

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Price £33.00

Includes free private prescriptions

In stock

2024/05/21 2024/05/22

Order before 15:00pm (Monday to Friday) for next day delivery