Vagifem Vaginal Tablets is an effective HRT for menopause. Buy Vagifem from Click Pharmacy today, we have a wide range of HRT available.


6/23/2025 4:02:12 PM


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Vagifem Vaginal Tablets

Vagifem is a type of medicine that menopausal women can use to ease discomfort caused by dryness and thinning of the vaginal tissues.

Medication features:

  • Treats vaginal symptoms connected to menopause
  • Contains estradiol hemihydrate
  • Comes in tablet form and needs to be inserted into the vagina

Next Day Delivery Available

UK Registered Pharmacy

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Expected Delivery: Tuesday

If you order within: 12h36m

Vagifem Vaginal Tablets Prices

  • Medicine prices
  • Delivery Information
Medicine Quantity Price
Vagifem Vaginal Tablets 10mcg 24 Tablets £38.99
Vagifem Vaginal Tablets 10mcg 48 Tablets £76.99

Delivery charges

Orders approved by our medical team before 3pm Monday – Friday are dispatched the same day via Royal mail. All orders are sent using a tracked and signed for service. Orders are not dispatched on weekends and bank holidays.

Royal Mail 1st Class | £3.95

Delivered within 1-3 working days. Excludes bank holidays. A tracked service with signature required on delivery.

Royal Mail Special Delivery Guaranteed before 1pm | £6.95

Delivered within 1 working day before 1pm. Excludes Sundays and bank holidays. A tracked service with signature required on delivery.

Find out more about our delivery service.

Refunds and returns – Read further information on return and refunds.

  • Overview
  • Directions
  • Cautions

Buy Vagifem Online UK

You can order Vagifem online in the UK from our registered pharmacy. Complete the online medical assessment to be reviewed by one of our prescribers. If approved, your medication will be dispensed by our pharmacy team for next day delivery to your address. 

About Vagifem Vaginal tablets

During menopause, the woman's body stops producing the same oestrogen levels. In turn, women can begin to suffer from symptoms such as pain during and after sex, irregular bleeding and spotting, as well as dryness and irritation of the vagina. These issues stem from vaginal atrophy, the thinning, inflammation and drying of the vaginal walls due to the lowered oestrogen levels.  

There are ways to ease these vaginal symptoms without taking oral medication. Vagifem is in tablet form and can be inserted with an easy-to-use applicator directly into the vagina and contains the naturally occurring oestrogen known as estradiol.  

As of right now, Vagifem tablets are only available in 24 packs of 10mcg strength.

Vagifem Summary Information

Type of medicine

Vaginal hormone replacement therapy (HRT) medication


Relieves symptoms of vaginal atrophy and dryness in menopausal women

How it works

Restores moisture and elasticity in the vaginal area

Active Ingredient


Directions of use

Vaginal tablets inserted into the vagina

Available strengths


Side effects

Common side effects include Vaginal irritation, itching, discharge, headaches, fluid retention


Store at room temperature



The information provided in the summary table is for reference only. It is important to consult a qualified healthcare professional before starting any menopause treatment, including Vagifem.

What is contained in Vagifem?

The active ingredient in each tablet is estradiol

The inactive ingredients are:

  • hypromellose
  • lactose monohydrate
  • maize starch
  • magnesium stearate.

The tablet coating contains:

  • hypromellose
  • macrogol 6000

If you are allergic to lactose or intolerant to it, please let your doctor know this before using this treatment.

How effective is Vagifem?

Vagifem treats vaginal symptoms connected to menopause. The hormone is absorbed directly where needed, increasing the oestrogen lost in the vagina and making it effective at easing issues such as soreness, pain during intercourse, vaginal dryness, itching and pain when urinating.


How should I take Vagifem?

Each dose of Vagifem is contained in a single tablet which can be inserted easily with a disposable, pre-filled applicator.  

  • Wash your hands before beginning.
  • Tear off and open an applicator
  • Ensure the tablet is securely inside
  • If the tablet or applicator falls onto the floor, throw them away and get a new one.
  • Insert the applicator into the vagina as you would a tampon
  • Push the free end down, releasing the tablet where it will slowly dissolve and release the dose
  • Throw the applicator away after use

You can use Vagifem at the most convenient time for you but aim to do it at the same time each day. This helps ensure that the oestrogen levels remain balanced. This will further help to stop the recurrence of your painful or uncomfortable symptoms. 

How long can I take Vagifem for?

As hormone treatments are used at their lowest effective dose and for the shortest time possible, the patients should use Vagifem once a day for the first 14 days and then twice a week thereafter. Your doctor will advise you on how and when to take this product, and it is important you follow their direction to ensure you get the most benefit out of your prescription.

In studies, many women felt the benefits within a matter of weeks.

Side effects

Follow are the common side effects for Vagifem Vaginal tablets

  • Headache or migraine
  • Stomach pain or sensitivity 
  • Vaginal bleeding
  • Vaginal discharge or discomfort
  • A fungal infection of the genitals (yeast infection)
  • Nausea (feeling sick)
  • Rash or hives
  • Fluctuation in weight
  • Hot flushes (sudden feeling of warmth all over your neck, face and body)
  • Hypertension or high blood pressure
  • Breast cancer
  • Endometrial cancer
  • Hypersensitivity
  • Allergy or shock
  • Fluid retention which may cause swelling in the limbs
  • Insomnia or other sleeping complications
  • Deep vein thrombosis (blood clot in the leg)
  • Diarrhoea or bloating
  • Itching 
  • Endometrial hyperplasia (thickening of the womb lining)
  • Irritation in the vagina
  • Pain in the vagina
  • Vaginal ulceration

Other warnings to consider

Most HRTs come in a combined format with both oestrogen and progesterone together because the progesterone helps to reduce the risk of cancer, stroke and blood clots, which are all potential side effects of hormone therapies. As such, if you have had or currently have cancer of the breast or womb, then Vagifem is not recommended.

Unusual bleeding can indicate cancer, so if you have experienced this, then ensure your doctor investigates before beginning a prescription for Vagifem.

For patients who are pregnant, allergic to the ingredients or for anyone who has experienced problems with their liver, then Vagifem is not recommended.


Vagifem Vaginal Tablets Reviews

How to order medications from us

Order your medication in a few clicks. Our process is easy, fast and secure.

Step 1

Short Medical Assessment

Fill out a questionnaire so our prescriber can assess if the treatment is suitable for you.

Step 2

Select Preferred Medication

Choose the medication you require from the range offered by our online pharmacy.

Step 3

Next Day

Add delivery details and complete payment process.

Price £38.99

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Available strengths:



Price £38.99

Includes free private prescriptions

In stock

2024/06/23 2024/06/24

Order before 15:00pm (Monday to Friday) for next day delivery