Medication features:

  • A short-term treatment for menopause
  • Contains medroxyprogesterone Acetate and oestrogens
  • Alleviates the symptoms of menopause


Available strengths:



Price £24.99

Includes free private prescriptions

In stock

Delivery Time


Expected delivery date:

Wednesday, 13 December 2023

If you order within:


Next Day Delivery

Next Day

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UK Registered Pharmacy

UK Registered

Discreet & Confidential

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  • Overview
  • FAQ
  • Side Effects
  • Patient Information Leaflet
  • Reviews

What is Premique

Premique, in essence, is a Hormone Replacement Therapy (HRT). It has two active ingredients, which are types of female hormones – estrogen and a progestogen (medroxyprogesterone acetate). These imitate the working of the female sex hormones oestrogen and progesterone in order to treat symptoms of menopause. It is also beneficial in helping reduce the risk of developing endometrial cancer, which is associated with taking oestrogen-only HRT in women with an undamaged uterus.

It might take a while for your body to adjust to Premique. During the initial stages, you may experience breakthrough bleeding or spotting. Since HRT should only be used as a short-term treatment for menopause, it is necessary to inform your primary physician if you experience spotting for an extended period of time.

Also, Premique is not birth control, nor will it act like one. Premique can not prevent pregnancy in women. Keep in mind that women are considered fertile until two years after their final menstrual cycle.

What Does Premique Treat?

At its core, Premique is a hormone replacement therapy (HRT) designed to help relieve the symptoms of menopause. Women usually tend to go through menopause between the ages of 45 and 55. During this period of time, the ovaries tend to produce less and less oestrogen. This lack of production of oestrogen is directly responsible for halting the menstrual cycle.

Although menopause is considered a natural part of a woman's ageing process and is a part of life, it can result in symptoms that can negatively impact an individual's everyday life. There are various manifestations of the physical symptoms, which can vary depending on the person. However, the most common ones are:

  • Night Sweats
  • Hot Flashes (intense feeling of warmth, usually over the face, neck and chest)
  • Dryness in the Vagina
  • Dryness of the Eyes
  • Osteoporosis
  • Insomnia or other sleeping disorders
  • Depression
  • Mood Swings
  • Irritability or Aggravation

Such physical symptoms generally last for more than four years. However, keep in mind that these kinds of symptoms may begin several years before the menopause period starts.

How does Premique Work?

Since Premique is a Hormone Replacement Therapy (HRT), it works by alleviating the symptoms of menopause by taking the levels of hormones up to a normal amount. Such hormones that the body used to produce naturally before menopause began are essential to a well-functioning body. However, some HRT medicines contain oestrogen only because the uncontrolled increase in oestrogen levels in women who still have a uterus can cause the lining of the uterus to expand significantly. As a result, the risk of endometrium cancer increases. In order to counter such risks, Premique contains progesterone.

How Should I Take Premique?

It is best to take Premique at a similar time every day. You can take the tablet with water. However, it is not necessary for you to eat something before or after. Avoid skipping doses and once the pack of Premique (28 tablets) runs out, start a new one immediately. Make sure there are no intervals. Review HRT with your primary physician every 6 months.

It is important to note that if you forget to take a tablet, for whatever reason, take it as soon as possible. This does not mean you should take two tablets at the same time. However, if the time for the next tablet has approached, then skip the missed dose.

Can I Purchase Premique Online?

It is necessary for one to have access to their essential medication at all times. It is also important to have an online pharmacy that you can trust. By placing an order through Click Pharmacy, you can purchase Premique safely and discreetly. We offer quick delivery, which means you can receive your order through our next-day delivery service. 

What are the Benefits of Using Premique?

As we all know, starting menopause indicates decreasing levels of oestrogen. This decrease in oestrogen can lead to several symptoms, including hot flushes, night sweats, as well as vaginal dryness. Premique and Premique Low Dose are effective hormone replacement therapy treatments that help to alleviate the symptoms of menopause. This treatment is also beneficial in slowing down the development of osteoporosis. Osteoporosis can often occur after menopause – only if the other treatment has proved unsuccessful.

What Does Premique Contain?

There are various inactive ingredients in Premique. However, the main active ingredients within this medicine are:

  • Medroxyprogesterone Acetate (Conjugated)
  • Oestrogens (Conjugated)

Premique’s Contraindications

Do not take Premique if you:

  • Have a blood clot or have experienced a blood clot in the past
  • Have had a heart attack or stroke recently
  • Struggle with angina pectoris
  • Have had breast cancer
  • Have had endometrial cancer
  • Have experienced endometrial hyperplasia
  • Have experienced abnormal vaginal bleeding
  • Currently have a condition which increases the risk of having a blood clot
  • Currently have a certain liver condition(s)
  • Have or had porphyria
  • Are pregnant
  • Are breastfeeding
  • Are allergic to any of the ingredients in Premique

Consult a doctor before taking Premique if you:

  • Have a family history of breast cancer
  • Have a condition that increases the risk of blood clots (such as obesity, high cholesterol, diabetes)
  • Have or had benign breast lumps
  • Have or had experienced endometriosis
  • Have or had fibroids in the womb
  • Have a family history of blood clots
  • Have a family history of high blood pressure (hypertension)
  • Have high blood pressure
  • Have or had complications with your kidneys
  • Have or had gallbladder disease
  • Experience migraines
  • Have or had systemic lupus erythematosus
  • Have or had epilepsy
  • Have or had asthma
  • Have or had otosclerosis

Cease the use of Premique and seek medical attention right away if you experience any of the following:

Blood clots: You may experience pain, swelling in the legs, and difficulty breathing.

Stroke: You may experience sudden migraines and blurred vision.

Heart disease: You may experience chest pain extending to the neck or arm (often on the left side).

Liver disease: You may notice the yellow colouration of the skin or eyes.

Medications that can interfere with Premique

It is of utmost importance that you are completely open and honest with your doctor when discussing the medicines you are currently taking. This includes medicines bought without a prescription, along with herbal medicines. Through this information, your doctor or local pharmacist can advise you on which medicines will have a negative effect on your body when mixed with Premique. Inform your doctor beforehand if you are taking any of the following medications:

  • Antiepileptic Medicines or Medication for Epilepsy, such as carbamazepine, phenytoin, phenobarbital and primidone.
  • Barbiturates, like amobarbital.
  • Medication for an HIV Infection like nevirapine or efavirenz.
  • Protease Inhibitors for an HIV infection like ritonavir and nelfinavir.
  • Rifamycin Antibiotics like rifabutin and rifampicin.

The herbal treatment known as St. John's Wort (Hypericum Perforatum).

Side Effects of Premique

Similar to most medications, Premique may cause some side effects. However, not every person will experience these side effects, and they may even differ depending on the person. The common side effects of Premique include but are not limited to breast pain, tenderness and nipple discharge, muscle ache, joint ache, fluctuation in weight, and breakthrough vaginal bleeding or spotting.

You may experience some serious side effects, as well. These include alteration in triglyceride levels and mood, complications with the heart or kidneys, blood clots, and headaches.

What dosage of Premique should I take?

Premique is only available in one dose, and it is considered a relative dose low. It is known as Premique Low Dose. Each tablet of Premique Low Dose contains around 300 micrograms of conjugated oestrogen — also referred to as equine. It also consists of 1.5 milligrams of medroxyprogesterone.

Is Premique Available in Other Forms?

Although you can find other HRT treatments in the form of creams, patches, tablets or implants, Premique is only available in the tablet form and only taken orally. However, there are different dosages of Premique available, which can be adjusted according to the guidance of your primary physician.

Why is Premique Prescribed for Treating Menopause Symptoms?

As mentioned, one of Premique's active ingredients is medroxyprogesterone acetate. This ingredient has been an effective treatment for treating menopause symptoms for over 30 years. Premique is one of the few medicines that are completely safe for short-term use for women going through menopause or premenopause.

How Long Can I Use Premique For?

Since Premique is supposed to be a short-term treatment for menopause symptoms, it is vital to remember that it should not be used for more than 5 years. The ideal period is less than 4 years.

Can I Take Premique If I am Breastfeeding or Pregnant?

Since this medication is intended for post-menopausal women only, it is not wise to take Premique if you are pregnant or breastfeeding.

If you are currently pregnant, trying to get pregnant or may think that you are pregnant, then you should not take this medicine and inform your doctor of such circumstances.

Has Premique Been Discontinued?

The high-dose Premique tablets (0.625mg/5mg) have been discontinued. However, the low-dose Premique is still available and can be purchased with a prescription as it is not an OTC medication

● Gut disturbances, like queasiness, vomiting, abdominal pain, bloating, flatulence, and indigestion.
● Menstrual bleeding or spotting.
● Vaginal thrush.
● Uterine fibroids' size increases.
● Breast pain or tenderness.
● Fluid retention.
● Swelling.
● Headache.
● Premenstrual-like symptoms.
● Depression, anxiety, aggravation or mood changes.
● Changes in sex drive.
● Exhaustion.
● Vertigo.
● Weight fluctuations.
● Leg cramps.
● Spike in blood pressure.
● Uncommon brown patches on the skin (chloasma).
● Complications with liver function.
● Jaundice.
● Gallbladder disease.
● Inflammation of the pancreas (pancreatitis).
● Blood clots in the blood vessels.

Always read the patient information leaflet before starting your treatment. The patient information can be found here

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