- Side Effects
- Patient Information Leaflet
What is Kliovance
Kliovance is a continuous combined form of hormone replacement therapy (HRT) used to treat menopause and premenopause symptoms. Each tablet of Kliovance contains two active ingredients, which fundamentally mimic the two female sex hormones the female body produces naturally before menopause begins. One is a natural version of oestrogen (also known as estradiol) and a synthetic version of progestogen (norethisterone). As compared to other hormone replacement therapy (HRT) treatments, Kliovance has a relatively lower dose of oestrogen and progesterone. This means that Kliovance is suitable for women who tend to be on the sensitive side when it comes to hormones.
Usual forms of HRT contain the active ingredient oestrogen only. However, such forms of HRT can cause complications in women who still have a uterus. That is because an uncontrolled increase in oestrogen levels leads the lining of the uterus (the endometrium) to grow excessively. This excessive increase can cause cancer. In order to combat this risk, Kliovance tablets contain about 0.5mg of norethisterone acetate, a synthetic version of progesterone.
Kliovance does not indicate a regular period. Due to this, Kliovance is best suited for individuals who have already reached menopause and are experiencing physical symptoms.
Can I buy Kliovance online?
Yes, it is easy to purchase a continuous form of combined HRT online. Kliovance is available readily for those who wish to order it through Click Pharmacy. However, it requires a prescription to gain access to Kliovance. Our health experts review the order and will determine whether or not the medication is a suitable choice for you.
What is Kliovance used for?
The primary purpose of Kliovance is to treat the physical symptoms of menopause, such as hot flushes, vaginal dryness, and others. It is a short-term treatment intended to be used by individuals who have not yet had a hysterectomy (removal of the uterus).
Also, Kliovance acts as an alternative treatment that can help prevent osteoporosis –particularly in women who have gone through menopause. Furthermore, for those who have tried other treatments and have not achieved satisfaction through those treatments.
How does Kliovance work?
Kliovance tablets contain two active ingredients, known as oestradiol hemihydrate and norethisterone acetate. These active ingredients imitate the function of the main female sex hormones, oestrogen and progesterone. Oestradiol is a naturally occurring form of oestrogen, whereas norethisterone is a manufactured form of progesterone.
Due to menopause, women's ovaries gradually produce less and less oestrogen. As a result, the oestrogen blood levels decline rapidly. The declining levels of oestrogen can be responsible for causing uncomfortable physical symptoms, such as irregular periods, hot flushes, night sweats, mood swings, depression and vaginal dryness or itching.
Oestrogen is often given as a supplement to substitute for the declining levels in the body, which also helps decrease the intensity of the painful symptoms of menopause. Similarly, a progestogen is required as part of HRT for women who still have an intact uterus. This is because, in women without a hysterectomy, oestrogen stimulates the growth of the womb lining (endometrium), leading to endometrial cancer. A progestogen opposes the effect of oestrogen on the uterus lining, which in return, reduces the risk of cancer. This type of treatment is a combined HRT.
As mentioned, Kliovance is a continuous form of combined HRT. Each tablet contains both essential actives, so a dose of both hormones is taken daily.
How effective is Kliovance?
Since Kliovance is a type of combined HRT, the effectiveness of the medication is excellent. In addition, it is deemed very effective when treating a wide range of symptoms women experience during menopause, such as hot flushes, night sweats, insomnia, vaginal dryness, irritability, depression, and more.
What does Kliovance contain?
The active ingredients contained in Kliovance tablets are 1mg of oestradiol (as estradiol hemihydrate) and 0.5mg of norethisterone acetate.
In addition to active ingredients, Kliovance tablets contain inactive ingredients, such as lactose monohydrate, maise starch, copovidone, talc, magnesium stearate, hypromellose, as well as triacetin.
How should I take Kliovance?
You should take one Kliovance tablet on a daily basis. Also, it should be continuous with no breaks between packs of Kliovance. You should take the tablets with water. However, you can take Kliovance with or without food.
It is vital to take your tablet around the same time each day. There are various benefits to this; the most important is that you will remember to take it if it becomes a daily practice.
In any case, if you forget to take a dose at your usual time and only a few hours have passed, you should take the missed dose. However, keep in mind that if 12 hours have passed since your missed dose, it is best to skip it and take the next one during the usual time. If it is less than 12 hours late when you remember, you should take the forgotten dose. Never take a double dose in order to make up for the missed dose.
What are the Side Effects of Kliovance?
All medicines have possible side effects that can affect individual people in various different ways. Remember that not everyone experiences side effects, and if they do, the side effects may not be identical. This is because side effects differ depending on the individual.
Possible side effects may include gut disturbances, such as nausea and vomiting, abdominal pain, bloating, flatulence, indigestion, menstrual bleeding or menstrual spotting, and vaginal thrush. You may also experience a growth in the size of uterine fibroids, pain, tenderness, sensitivity or enlargement in the breast, and fluid retention, which may cause swelling (oedema). Other possible side effects may be headache or migraine, premenstrual-like symptoms, depression, anxiety, irritability or mood swings, changes in libido, tiredness, vertigo, fluctuation in weight, and leg cramps along with a spike in blood pressure, sudden skin reactions such as rash and itching, irregular brown patches on the skin often occurring on the face (chloasma), complications with liver function which can lead to jaundice, gallbladder disease, pancreatitis, and blood clots which can lead to a stroke, heart attack, and more.
What are the benefits of taking Kliovance?
Kliovance is a treatment made to help relieve menopausal symptoms in post-menopausal women. The primary objective of Kliovance is to help achieve an average amount of oestrogen levels in the body. Kliovance helps the levels get back to a similar level to what they were before menopause. By stabilising the oestrogen levels, the intensity of hot flashes is reduced significantly. In addition to this, it helps manage and control other symptoms, such as night sweats, vaginal dryness and itching.
The treatment is a dual HRT treatment, which also consists of artificial progestogen. Due to this, Kliovance is only recommended to women who still have an intact uterus.
What precautions or interactions should I be aware of when taking Kliovance?
Do not take Kliovance unless your doctor recommends it. It is not birth control, nor does it act like one. Various other precautions should be carefully considered before you decide to take Kliovance. Do not use Kliovance if you:
- Have a history of breast cancer
- Have a history of endometriosis
- Have a history of asthma
- Have a history of depression
- Have a history of gallbladder disease
- Currently have heart disease, kidney problems, diabetes, obesity, high blood pressure, or hypertension
- Have a history of epilepsy
- Recently had a stroke or heart attack
- Are pregnant or breastfeeding
- Are allergic to the active ingredients oestradiol or norethisterone
What is menopause?
Menopause is something that all women go through once in their lives. Typically, it occurs between the ages of 45 and 55. Menopause occurs when you reach a certain age, and your ovaries begin to produce less and less oestrogen. Due to this imbalance, the menstrual cycle stops, and changes in hormone levels occur. This can lead to several symptoms that may significantly impact day-to-day life.
Physical symptoms may include:
- hot flushes (a sudden heat that spreads throughout the body, which can lead to blushing, sweating and an unusual heartbeat)
- night sweats
- dryness of the eyes
- dryness of the vagina
- increased irritability
It is crucial to remember that every person's experiences with menopausal symptoms vary significantly. Some experience the symptoms before menopause hits, and some continue to experience them even after menopause ends.
How does HRT work?
Hormone replacement therapy helps ease the symptoms of menopause by stabilising the levels of hormones in the body that the body does not produce naturally. For example, each Kliovance tablet has the same amount of oestrogen and progesterone. Due to this, women do not experience a monthly bleed while taking this form of HRT.
However, note that as the body adjusts to Kliovance, some women may experience breakthrough bleeding or spotting. This is a normal response. But, if it continues over the span of a few months of treatment, stop taking it and inform your GP.
Is Kliovance right for me?
Kliovance is an effective HRT. However, it may not be as effective for everyone as the efficacy varies from person to person. A few conditions tend to interact with Kliovance, which can make the treatment less potent. Do not take Kliovance if you have, or have had any of the following:
- breast cancer
- high blood pressure
- blood clots
- gallbladder problems
- vaginal bleeding
- liver disease
Kliovance can interact with:
- HIV medications
- medicines used to treat epilepsy
- John’s wort
- antifungal medicines
Is Kliovance the same as Kliofem?
Kliovance and Kliofem are pretty similar.
Not only are they both oral tablets used to treat the symptoms of menopause, but they also contain the same active ingredients. However, the critical difference is that Kliofem contains twice as much estradiol and progestogen as Kliovance. So, Kliofem is significantly stronger than Kliovance.
Do I need a prescription to purchase Kliovance Tablets?
Yes, you need a prescription in order to purchase Kliovance tablets. However, if you do not have one, you can consult our medical experts available via our website to get a consultation. Through this consultation, it will be determined whether you require the assistance of Kliovance or not. If yes, then you can order the medication through our website.
Can I take Kliovance Tablets on an empty stomach?
Yes, you are not required to eat anything before taking Kliovance. However, taking the tablets with a glass of water is recommended.
What if I forget to take my dose of Kliovance Tablets?
If you forget to take your dose of Kliovance tablets under any circumstances, you should check how much time has passed since your missed dose. You can safely take your forgotten dose if it has been less than 12 hours. However, if more than 12 hours have passed, you should skip your missed dose and take the next one at the usual time.
Which medication interacts with Kliovance?
Kliovance can interact with:
- HIV medications
- Medicines used to treat epilepsy
- John's wort
- Diltiazem (used to treat high blood pressure)
- Antifungal medicines
How long does it typically take for Kliovance to work?
HRTs alleviate menopause symptoms at a rapid pace. In fact, most women begin noticing an improvement in their symptoms within the first 10 to 14 days of Kliovance. However, this may vary from woman to woman.
How long do I use Kliovance for?
You should never take HRT for more than five years. This rule applies to Kliovance, too. Most women often only take it for a few years until their menopause symptoms eventually subside. However, you should always discuss your condition with your doctor.
Possible side effects of Kliovance include:
● Fluid retention which may cause swelling
● Weight gain
● Vaginal inflammation or infection (thrush)
● Breast problems (pain, tenderness, enlargement, swelling)
● Back pain
● Uterine fibroids (either an increase in size or the appearance of)
● Mood changes
● Abdominal pain or discomfort
● Digestive issues
● Hair loss
● Abnormal hair growth
● Leg cramps
● Blood clots in the blood vessels (stroke, heart attack etc.)