Kliovance is a type of combined HRT and treats the physical symptoms of menopause, such as hot flushes and others. Buy Kliovance today from Click Pharmacy.


6/23/2025 3:02:25 PM


Images are for illustration purposes only.

Kliovance Tablets

Kliovance is a type of hormone replacement therapy (HRT) used to ease menopause symptoms like hot flashes, night sweats, and vaginal dryness.

Medication features:

  • Continuous combined hormone replacement therapy 
  • Contains estradiol and norethisterone
  • Treats menopause and premenopause symptoms

Next Day Delivery Available

UK Registered Pharmacy

Price Match Guarantee

Expected Delivery: Tuesday

If you order within: 12h36m

Kliovance Prices

  • Medicine prices
  • Delivery Information
Medicine Quantity Price
Kliovance 1mg/500mcg 84 Tablets £29.99

Delivery charges

Orders approved by our medical team before 3pm Monday – Friday are dispatched the same day via Royal mail. All orders are sent using a tracked and signed for service. Orders are not dispatched on weekends and bank holidays.

Royal Mail 1st Class | £3.95

Delivered within 1-3 working days. Excludes bank holidays. A tracked service with signature required on delivery.

Royal Mail Special Delivery Guaranteed before 1pm | £6.95

Delivered within 1 working day before 1pm. Excludes Sundays and bank holidays. A tracked service with signature required on delivery.

Find out more about our delivery service.

Refunds and returns – Read further information on return and refunds.

  • Overview
  • Directions
  • Cautions

Buy Kliovance Online UK

You can order Kliovance online in the UK from our registered pharmacy. Complete the online medical assessment to be reviewed by one of our prescribers. If approved, your medication will be dispensed by our pharmacy team for next day delivery to your address. 

About Kliovance

Kliovance is a continuous combined form of hormone replacement therapy (HRT) used to treat menopause and premenopause symptoms. Each tablet of Kliovance contains two active ingredients, which fundamentally mimic the two female sex hormones the female body produces naturally before menopause begins. One is a natural version of oestrogen (also known as estradiol) and a synthetic version of progestogen (norethisterone). As compared to other hormone replacement therapy (HRT) treatments, Kliovance has a relatively lower dose of oestrogen and progesterone. This means that Kliovance is suitable for women who tend to be on the sensitive side when it comes to hormones.

Usual forms of HRT contain the active ingredient oestrogen only. However, such forms of HRT can cause complications in women who still have a uterus. That is because an uncontrolled increase in oestrogen levels leads the lining of the uterus (the endometrium) to grow excessively. This excessive increase can cause cancer. In order to combat this risk, Kliovance tablets contain about 0.5mg of norethisterone acetate, a synthetic version of progesterone.

Kliovance does not indicate a regular period. Due to this, Kliovance is best suited for individuals who have already reached menopause and are experiencing physical symptoms.

Kliovance Summary Information

Type of medicine

Hormone replacement therapy (HRT) medication


Relieves symptoms of menopause

How it works

Contains estradiol and norethisterone acetate to restore hormonal balance

Active Ingredient

Estradiol, Norethisterone Acetate

Directions of use

Oral tablets

Available strengths


Side effects

Common side effects include Gut disturbances, nausea and vomiting, abdominal pain, bloating, flatulence, indigestion, menstrual bleeding or menstrual spotting



The information provided in the summary table is for reference only. It is important to consult a qualified healthcare professional before starting any menopause treatment, including Kliovance.

What is Kliovance used for?

The primary purpose of Kliovance is to treat the physical symptoms of menopause, such as hot flushes, vaginal dryness, and others. It is a short-term treatment intended to be used by individuals who have not yet had a hysterectomy (removal of the uterus).

Also, Kliovance acts as an alternative treatment that can help prevent osteoporosis –particularly in women who have gone through menopause. Furthermore, for those who have tried other treatments and have not achieved satisfaction through those treatments.

How does Kliovance work?

Kliovance tablets contain two active ingredients, known as oestradiol hemihydrate and norethisterone acetate. These active ingredients imitate the function of the main female sex hormones, oestrogen and progesterone. Oestradiol is a naturally occurring form of oestrogen, whereas norethisterone is a manufactured form of progesterone.

Due to menopause, women's ovaries gradually produce less and less oestrogen. As a result, the oestrogen blood levels decline rapidly. The declining levels of oestrogen can be responsible for causing uncomfortable physical symptoms, such as irregular periods, hot flushes, night sweats, mood swings, depression and vaginal dryness or itching.

Oestrogen is often given as a supplement to substitute for the declining levels in the body, which also helps decrease the intensity of the painful symptoms of menopause. Similarly, a progestogen is required as part of HRT for women who still have an intact uterus. This is because, in women without a hysterectomy, oestrogen stimulates the growth of the womb lining (endometrium), leading to endometrial cancer. A progestogen opposes the effect of oestrogen on the uterus lining, which in return, reduces the risk of cancer. This type of treatment is a combined HRT.

As mentioned, Kliovance is a continuous form of combined HRT. Each tablet contains both essential actives, so a dose of both hormones is taken daily.

How effective is Kliovance?

Since Kliovance is a type of combined HRT, the effectiveness of the medication is excellent. In addition, it is deemed very effective when treating a wide range of symptoms women experience during menopause, such as hot flushes, night sweats, insomnia, vaginal dryness, irritability, depression, and more.

What does Kliovance contain?

The active ingredients contained in Kliovance tablets are 1mg of oestradiol (as estradiol hemihydrate) and 0.5mg of norethisterone acetate.

In addition to active ingredients, Kliovance tablets contain inactive ingredients, such as lactose monohydrate, maise starch, copovidone, talc, magnesium stearate, hypromellose, as well as triacetin.

What are the benefits of taking Kliovance?

Kliovance is a treatment made to help relieve menopausal symptoms in post-menopausal women. The primary objective of Kliovance is to help achieve an average amount of oestrogen levels in the body. Kliovance helps the levels get back to a similar level to what they were before menopause. By stabilising the oestrogen levels, the intensity of hot flashes is reduced significantly. In addition to this, it helps manage and control other symptoms, such as night sweats, vaginal dryness and itching.

The treatment is a dual HRT treatment, which also consists of artificial progestogen. Due to this, Kliovance is only recommended to women who still have an intact uterus.


How should I take Kliovance?

You should take one Kliovance tablet on a daily basis. Also, it should be continuous with no breaks between packs of Kliovance. You should take the tablets with water. However, you can take Kliovance with or without food.

It is vital to take your tablet around the same time each day. There are various benefits to this; the most important is that you will remember to take it if it becomes a daily practice.

In any case, if you forget to take a dose at your usual time and only a few hours have passed, you should take the missed dose. However, keep in mind that if 12 hours have passed since your missed dose, it is best to skip it and take the next one during the usual time. If it is less than 12 hours late when you remember, you should take the forgotten dose. Never take a  double dose in order to make up for the missed dose.

Side effects

All medicines have possible side effects that can affect individual people in various different ways. Remember that not everyone experiences side effects, and if they do, the side effects may not be identical. This is because side effects differ depending on the individual.

Possible side effects may include

  • gut disturbances,
  • nausea and vomiting,
  • abdominal pain,
  • bloating,
  • flatulence,
  • indigestion,
  • menstrual bleeding or menstrual spotting,
  • vaginal thrush.

You may also experience a growth in the size of uterine fibroids, pain, tenderness, sensitivity or enlargement in the breast, and fluid retention, which may cause swelling (oedema). Other possible side effects may be headache or migraine, premenstrual-like symptoms, depression, anxiety, irritability or mood swings, changes in libido, tiredness, vertigo, fluctuation in weight, and leg cramps along with a spike in blood pressure, sudden skin reactions such as rash and itching, irregular brown patches on the skin often occurring on the face (chloasma), complications with liver function which can lead to jaundice, gallbladder disease, pancreatitis, and blood clots which can lead to a stroke, heart attack, and more.

What precautions or interactions should I be aware of when taking Kliovance?

Do not take Kliovance unless your doctor recommends it. It is not birth control, nor does it act like one. Various other precautions should be carefully considered before you decide to take Kliovance. Do not use Kliovance if you:

  • Have a history of breast cancer
  • Have a history of endometriosis
  • Have a history of asthma
  • Have a history of depression
  • Have a history of gallbladder disease
  • Currently have heart disease, kidney problems, diabetes, obesity, high blood pressure, or hypertension
  • Have a history of epilepsy
  • Recently had a stroke or heart attack
  • Are pregnant or breastfeeding
  • Are allergic to the active ingredients oestradiol or norethisterone

Kliovance Reviews

How to order medications from us

Order your medication in a few clicks. Our process is easy, fast and secure.

Step 1

Short Medical Assessment

Fill out a questionnaire so our prescriber can assess if the treatment is suitable for you.

Step 2

Select Preferred Medication

Choose the medication you require from the range offered by our online pharmacy.

Step 3

Next Day

Add delivery details and complete payment process.

Price £29.99

Price Checker


Available strengths:



Price £29.99

Includes free private prescriptions

In stock

2024/06/23 2024/06/24

Order before 15:00pm (Monday to Friday) for next day delivery