Estriol Cream is an effective HRT for menopause. Buy Estriol Cream from Click Pharmacy today, we have a wide range of HRT available.


6/23/2025 2:34:47 PM


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Estriol Cream

Estriol cream is a lotion that women can put on their private parts to help with problems like dryness and discomfort during menopause.

Medication features:

  • Treats the thinning of the cells lining of the urethra and vagina
  • Contains estriol
  • Combats vaginal dryness and other symptoms associated with it

Next Day Delivery Available

UK Registered Pharmacy

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Expected Delivery: Tuesday

If you order within: 12h36m

Estriol Cream Prices

  • Medicine prices
  • Delivery Information
Medicine Quantity Price
Estriol Cream 80g 1 Tube £47.99
Estriol Cream 80g 2 Tubes £89.99
Estriol Cream 80g 3 Tubes £129.99

Delivery charges

Orders approved by our medical team before 3pm Monday – Friday are dispatched the same day via Royal mail. All orders are sent using a tracked and signed for service. Orders are not dispatched on weekends and bank holidays.

Royal Mail 1st Class | £3.95

Delivered within 1-3 working days. Excludes bank holidays. A tracked service with signature required on delivery.

Royal Mail Special Delivery Guaranteed before 1pm | £6.95

Delivered within 1 working day before 1pm. Excludes Sundays and bank holidays. A tracked service with signature required on delivery.

Find out more about our delivery service.

Refunds and returns – Read further information on return and refunds.

  • Overview
  • Directions
  • Cautions

Buy Estriol Cream Online UK

You can order Estriol Cream online in the UK from our registered pharmacy. Complete the online medical assessment to be reviewed by one of our prescribers. If approved, your medication will be dispensed by our pharmacy team for next day delivery to your address. 

About Estriol Cream

When women reach menopause, several biological changes begin to occur, one of which is a decrease in oestrogen production. As a result of low oestrogen production, vaginal dryness occurs, which further leads to inflammation, itching as well as other painful symptoms. Such symptoms tend to affect the sensitive lining of the vagina. Due to such occurrences, the likelihood of one developing urinary and vaginal infections increases significantly.

In order to combat vaginal dryness and other symptoms associated with it, a hormone replacement therapy (HRT), known as Estriol Cream, is used. It can prove to be life-changing for most users.

Estriol Summary Information

Type of medicine

Hormone replacement therapy (HRT) medication


Relieves symptoms of vaginal atrophy and dryness in menopausal women

How it works

Contains estriol to restore moisture and elasticity in the vaginal area

Active Ingredient


Directions of use

Applied topically to the vaginal area as directed by a healthcare professional

Available strengths


Side effects

Common side effects include Vaginal irritation, itching, discharge, headaches, fluid retention



The information provided in the summary table is for reference only. It is important to consult a qualified healthcare professional before starting any menopause treatment, including Estriol.

What is contained in Estriol?

The primary active ingredient in each tube is Estriol. However, there are various inactive ingredients. They may include eutanol G, lactic acid, sodium hydroxide, purified water, sorbitan monostearate, cetyl palmitate, glycerol, stearyl alcohol, cetyl alcohol, polysorbate 60, as well as chlorhexidine hydrochloride.

How effective is Estriol?

Oestrogen cream is a very effective form of treatment for the thinning of the cells lining the urethra and vagina, as it helps restore the cells and pause the continued depletion. One major benefit to the cream being applied directly to the affected area is that the required dose is lower than orally taken oestrogen and yet still achieves highly effective results. Clinical trials demonstrated relief from symptoms of the vagina, such as dryness, itching and inflammation, during the first weeks of treatment.

Why choose Estriol?

Estradiol, estrone, and Estriol are the three naturally occurring oestrogen hormones. Since Estriol had always been considered the weakest of the three due to the level of its oestrogenic effects within the body, it had often been overlooked in the treatment of menopausal side effects. And yet, more recently, studies have discovered that due to this supposed weakness, it comes with fewer potential side effects and possible dangers than when using hormone replacement products with higher potency oestrogens. Issues linked to synthetic hormones circulating through the body when taken orally can include stimulating the ductal cells in the breast, uterine lining and endometrial cells, increasing the risk of cancers in these areas.

Conversely, studies so far have demonstrated that low-dose vaginal oestrogen creams did not instigate such stimulated growth when used over a long-term basis. It also gives a good alternative option to women who either cannot or do not want to use HRT tablets or patches.

How does Estriol work?

When menopause causes the vaginal tissues to thin, the resulting symptoms, such as dryness and inflammation, can be challenging to live with. The use of an oestrogen medication such as Estriol supplements the vagina with the oestrogen the ovaries no longer produce naturally, easing the symptoms and giving relief.


How should use Estriol?

The cream comes with a plastic application used to apply the correct amount of medication.

  • Remove the tube cap and open the tube if it is the first time you have used it
  • Screw the end of the applicator onto the tube
  • Squeeze the tube until the tube is filled up to the marker, signifying one dose.
  • Place the cap back on the tube once you have removed the applicator
  • Lie down, place the applicator into the vagina and push the free end down until the full dose is inserted.
  • Wash the barrel and plunger in hot soapy water and rinse well. Do not use detergents or boiling water on the applicator.
  • Stay lying down once applied, if possible, to avoid leaking.

For menopausal problems, you will usually be prescribed enough for one full applicator of cream to be used each night for either two or three weeks. This may then be reduced to twice a week once your symptoms decrease, but your doctor will discuss your current symptoms and give you a personalised prescription based on these and your answers in the medical assessment form.

You should take a break from using the cream every 8 to 12 weeks to discover whether you still require it. Your doctor can review the length of time it’s used for, as well as any necessary breaks.

How long can I use Estriol for?

Women are usually recommended to use the cream each night before bed for 2 or 3 weeks before lowering it to twice a week, but your doctor will discuss it with you.

It has been studied and seen to be safe for long-term use, with regular reviews by your doctor to ensure it is still the most appropriate and effective medication for you.

What are the side effects of Estriol?

Estriol can cause side effects, but not everyone will develop them. If you experience any of these side effects mentioned below or develop any other issues after using this cream, contact your doctor, who may decide to stop or change the treatment.

Side effects of Estriol cream may include

  • Irritation or itching in or around your vagina.
  • Excessive discharge.
  • Undiagnosed vaginal bleeding.
  • Rash or hives.
  • Sudden sensitivity to sunshine.
  • Swollen breasts.
  • Tender breasts.
  • Pain in breasts.
  • Headaches or migraines.
  • Nausea (feeling sick).
  • Symptoms of the flu.
  • Application site irritation and pruritis.
  • Fluid retention.
  • Postmenopausal spotting as well as vomiting.

Other warnings to consider

Levels of oestrogen absorbed into the bloodstream are very low due to being taken topically rather than orally or injected. As such, it is unlikely to affect any other medications you use but be sure to discuss other treatments you currently take with your doctor before starting Estriol to be certain.

Though studies have shown that oestrogen applied topically lowers the chance of developing more serious conditions such as cancer, it is always wise to assume that increased risks are possible. Keep this in mind, and make sure you book regular reviews of your treatment with your doctor.

Ensure you do not let other people touch the cream as it is absorbed through the skin, and they may get a dose of the oestrogen. Ensure to wash and dry your hands well after use for this exact reason.

Estriol Cream Reviews

How to order medications from us

Order your medication in a few clicks. Our process is easy, fast and secure.

Step 1

Short Medical Assessment

Fill out a questionnaire so our prescriber can assess if the treatment is suitable for you.

Step 2

Select Preferred Medication

Choose the medication you require from the range offered by our online pharmacy.

Step 3

Next Day

Add delivery details and complete payment process.

Price £47.99

Price Checker


Available strengths:



Price £47.99

Includes free private prescriptions

In stock

2024/06/23 2024/06/24

Order before 15:00pm (Monday to Friday) for next day delivery